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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
ProteomicsReverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
To determine the biological effects of MPS1 inhibition (both by siRNA and Drug (NMSP715)) on signaling pathways in GBM cells (U251 &U87), we profiled the modulation of phosphorylated and non-phosphorylated proteins using RPPA Relative protein levels for each sample were determined by interpolation o...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-67502 | biostudies-arrayexpress
GenomicsModulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role in inflammation. We report the development of the first small molecule SP140 inhib...
EGAS00001004460 | EGA
TranscriptomicsOleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.
Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide- mediate signaling in plant defense. Nitric Oxide, Oleic acid, Salicylic acid, Arabidopsis, Defense Wild-type Col-0, mutant genotypes ssi2, ssi2 act1 and ssi2 sid2 with three biological replicates were...
ORGANISM(S): Arabidopsis thaliana 
2012-07-31 | E-GEOD-36797 | biostudies-arrayexpress
TranscriptomicsCharacterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection
The unicellular eukaryote Entamoeba histolytica is a human parasite that causes amebic dysentery and liver abscess. A genome-wide analysis of gene expression modulated by intestinal colonization and invasion identified an up-regulated transcript that encoded a putative high-mobility-group box (HMGB)...
ORGANISM(S): Entamoeba histolytica 
2008-11-19 | E-GEOD-12204 | biostudies-arrayexpress
GenomicsGut microbiome modulation by cricket, pea, and whey protein
Gut microbiome modulation by cricket, pea, and whey protein Raw sequence reads
PRJNA1299316 | ENA
GenomicsSpecialized ribosomal protein genes promote drug resistance through modulation of translation
Specialized ribosomal protein genes promote drug resistance through modulation of translation
PRJNA551484 | ENA
GenomicsGut microbiome modulation by cricket, pea, and whey protein
16S rRNA sequencing of gut microbiota after cricket, pea, or whey protein intake Metagenome
PRJNA1280763 | ENA
GenomicsModulation of the DNA/RNA Binding Protein ARID5A Regulates Microglial Activation and Response
Modulation of the DNA/RNA Binding Protein ARID5A Regulates Microglial Activation and Response
PRJNA1230069 | ENA
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