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MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
MetabolomicsMetabolomics analysis was used to resolve metabolites affecting the protein oil content of soybean.
Soybean (Glycine max (L.)) originated in China more than 5000 years ago, and the country is currently the third largest producer of soybeans in the world (Hymowitz et al., 2015). Based on a wild soybean Chromosome Segment Substitution Line (CSSL) population were constructed by crossing with the cult...
2024-11-13 | MTBLS9424 | MetaboLights
MetabolomicsA multi-omics study on the metabolic reprogramming of a chlorophyll-deficient, high-protein Auxenochlorella pyrenoidosa mutant (CX41) generated by atmospheric and room temperature plasma (ARTP) mutagenesis.

This project aims to elucidate the molecular mechanism underlying the stable golden-yellow phenotype and enhanced protein accumulation in an Auxenochlorella pyrenoidosa mutant (CX41) generated by ARTP mutagenesis. Through comparative analysis between the wild-type (FACHB-9) and mutant s...

2025-12-26 | MTBLS13574 | MetaboLights
TranscriptomicsFunctional signature for the recognition of specific target mRNAs by human staufen1 protein
Cellular mRNAs are permanently associated to proteins in the form of ribonucleoprotein particles. In addition to the hnRNP and SR protein families, the double-stranded RNA-binding (DRB) proteins play important roles in mRNA synthesis, modification, activity and decay (Dreyfuss et al, 2002; Stutz & I...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-47226 | biostudies-arrayexpress
TranscriptomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (RNA-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67379 | biostudies-arrayexpress
ProteomicsProteomics data for: Pan-Apoptotic Protein Signature as a Novel Diagnostic and Prognostic Biomarker for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) remains a major cause of morbidity and mortality, with no rapid blood-based biomarkers available to assess secondary brain injury. This study aimed to identify a circulating pan-cell death protein signature for diagnosing and prognosing ICH. We prospectively enrolled 6...
ORGANISM(S): Homo Sapiens 
2025-12-11 | PXD071856 |
ProteomicsProteomic Analysis of Protein in Human Fingerprints and Artificial Fingerprints
Quantitative genomic and proteomic evaluation of human latent fingerprint depositions represents a challenge within the forensic field, due to the high variability in the amount of DNA and protein initially deposited. To better assess recovery techniques for touch depositions, we present a method to...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD015445 | Pride
Forensics Artificial fingerprint Latent fingerprint Protemics 
TranscriptomicsProtein P Vs Protein G
Rationale: Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Co-infection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. Objectives: To determine if interaction between RS...
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-21 | E-GEOD-58424 | biostudies-arrayexpress
GenomicsA signature protein of Mycobacterium tuberculosis (Rv000) modulates the transcriptome of Mycobacterium smegmatis.
A signature protein of Mycobacterium tuberculosis (Rv000) modulates the transcriptome of Mycobacterium smegmatis.
PRJNA523434 | ENA
TranscriptomicsAssociation of prognosis of acute myeloid leukemia patients with leukemia stem cell gene signature based on nucleostemin promoter activity
Acute myeloid leukemia (AML) is a heterogeneous neoplastic disorder, in which only a subset of cells have function as leukemia-initiating cells (LICs). In this study, we prospectively evaluated leukemia-initiating capacity of fractionated subpopulations of AML cells depending on expression of a nucl...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58032 | biostudies-arrayexpress
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