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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
ProteomicsLinking post-translational modifications and protein turnover by site-resolved protein turnover (SPOT) profiling
Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labelling and mass spectrometry to measure the turnover of >120,000 peptidoforms including >33,000 phosphorylated, acetylated and u...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD023218 | Pride
Human Ptms Turnover Silac 
ProteomicsProtein turnover analysis in Salmonella Typhimurium during infection by dynamic SILAC, Topograph and quantitative proteomics
Protein turnover affects protein abundance and phenotypes. Comprehensive investigation of protein turnover dynamics has the potential to provide substantial information about gene expression. Here we report a large-scale protein turnover study in Salmonella Typhimurium during infection by quantitati...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2022-05-17 | PXD033623 | Pride
Proteomics Salmonella typhimurium Dynamic silac Protein turnover 
ModelsXu2003 - Phosphoinositide turnover
Xu2003 - Phosphoinositide turnover The model reproduces the percentage change of PIP_PM, PIP2_PM and IP3_Cyt as depicted in Figure 1 of the paper. The model also contains the equations for the analysis of PH-GFP experiments, however the initial value of PH_GFP has been set to zer...
2024-09-02 | BIOMD0000000075 | BioModels
ProteomicsRibosomal protein turnover under normal condition
The cytosolic ribosome is composed of a large number of distinct protein types and its overall function is responsible for the synthesis of most proteins in plants. Defining the role of each of its protein subunits is a major challenge which is hampered by a lack of consistency in current attributi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-08-17 | PXD012839 | Pride
Arabidopsis cell culture 15n isotopic labelling Protein turnover 80s cytosolic ibosome isolation 
ProteomicsProtein turnover during C. elegans aging
Protein turnover rates severely decline in aging organisms, including C. elegans. However, limited information is available on turnover dynamics at the individual protein level during aging. We followed changes in protein turnover at one-day resolution using a multiple-pulse 15N-labeling and accurat...
ORGANISM(S): Caenorhabditis elegans 
2017-07-11 | PXD002901 | Pride
C. elegans Protein turnover Aging 
ProteomicsLinking post-translational modifications and protein turnover by site-resolved protein turnover (SPOT) profiling
Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labelling and mass spectrometry to measure the turnover of >120,000 peptidoforms including >33,000 phosphorylated, acetylated, and ...
ORGANISM(S): Homo Sapiens 
2022-03-14 | PXD023234 | panorama
ProteomicsBank Vole Protein Turnover Study C4PR_LIV
We have used dietary administration of stable isotope labelled lysine to assess protein turnover rates for proteins from four tissues in the bank vole, Myodes glareolus. The annotated genome for this species is not available, so protein identification was attained through cross-species matching to t...
ORGANISM(S): Mus musculus (Mouse) Myodes glareolus (Bank vole) (Clethrionomys glareolus) 
2016-02-09 | PXD002054 | Pride
Vole protein turnover 
TranscriptomicsLong noncoding RNA as regulatory switch of protein turnover
Long intervening noncoding RNAs (lincRNAs) are prevalent genes with poorly understood functions. Here we discover a pathway of lincRNA-regulated proteolysis. The enhancer-like lincRNA HOTTIP extends the half-life of its binding protein WDR5, a subunit of the MLL H3K4 methylase complex, resulting in ...
ORGANISM(S): Mus musculus 
2013-02-18 | E-GEOD-36513 | biostudies-arrayexpress
ProteomicsProtein turnover rate along the gastrointestinal tract is coordinated by the spatial location and the microbiota
The gastrointestinal tract is covered by a single layer of epithelial cells that, together with the mucus layers, protect the underlying tissue from bacterial invasion. The epithelium has one of the highest turnover rates in the body, renewing every 4-5 days. Using stable isotope labelling, high-res...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-24 | PXD011457 | Pride
Germ-free Colon Mass spectrometry Protein turnover Commensals Lipid metabolism Proteomics Colonization Small intestine Bacteria 
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