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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
Proteomics,MultiomicsDefining the effects of genetic variation on a proteome-wide scale
Genetic variation governs protein expression through both transcriptional and post-transcriptional processes. To investigate this relationship, we combined a multiplexed, mass spectrometry-based method for protein quantification with an emerging mouse model harboring extensive genetic variation fro...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-08 | MSV000081696 | MassIVE
GenomicsA role for tRNA modifications in the expansion of proteome diversity
A role for tRNA modifications in the expansion of proteome diversity
PRJNA633874 | ENA
TranscriptomicsA role for tRNA modifications in the expansion of proteome diversity
The mechanisms that drive the evolution of proteome diversity are poorly understood. Here we investigate the functional significance of eight eukaryotic tRNAs that contain inosine in the wobble position of the anticodon (I34-tRNAs). We find that these modified tRNAs are essential to translate a subs...
ORGANISM(S): Homo sapiens 
2021-06-28 | GSE150860 | GEO
ProteomicsThe natural diversity of the yeast proteome links aneuploidy tolerance to genome-wide proteome
Recent advancements in genome sequencing have facilitated accessing the natural genetic diversity of species, unveiling hidden genetic traits, clarifying gene functions, and the degree to which laboratory studies can be generalized. One notable discovery is the frequent (~20%) aneuploidy - an imbala...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-11 | PXD044526 | Pride
Large-scale Proteomics Lab-engineered strains Yeast Diversity Wild isolates High-throughput Aneuploidy 
TranscriptomicsThe mRNA-bound proteome and its global occupancy profile on protein-coding transcripts [RNA-seq]
Protein-RNA interactions are fundamental to core biological processes, such as mRNA splicing, localization, degradation and translation. We developed a photoreactive nucleotide-enhanced UV crosslinking and oligo(dT) purification approach to identify the mRNA-bound proteome using quantitative proteom...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-38356 | biostudies-arrayexpress
TranscriptomicsThe mRNA-bound proteome and its global occupancy profile on protein-coding transcripts [protein occupancy profiling]
Protein-RNA interactions are fundamental to core biological processes, such as mRNA splicing, localization, degradation and translation. We developed a photoreactive nucleotide-enhanced UV crosslinking and oligo(dT) purification approach to identify the mRNA-bound proteome using quantitative proteom...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-38355 | biostudies-arrayexpress
ProteomicsGlobal Proteome Analysis of the NCI-60 Cell Line Panel
The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-23 | MSV000082204 | MassIVE
UnknownRegional Diversity in the Postsynaptic Proteome of the Mouse Brain.
Not available
S-EPMC6161190 | biostudies-literature
UnknownAlternative splicing shapes transcriptome but not proteome diversity in Physcomitrella patens.
Not available
S-EPMC5457400 | biostudies-literature
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