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ProteomicsBiopsy proteome score performs well as an effect measure in a gluten-challenge trial of coeliac disease
Objective Development of novel treatments for coeliac disease (CeD) is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardise. Biopsy proteome scoring is an objective alternative to histology which is bas...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD050655 | Pride
Human Proteome score Gut biopsy Evosep Timstofflex Clinical trial 
TranscriptomicsA proteomic view on the cell biology of Staphylococcus aureus proteome
The genome sequence is the “blue-print of life”, but proteomics is required to relate this blue-print of life to the actual physiology of living cells. Because of their low complexity – only about 2.000 proteins make a Staphylococcus aureus cell viable – bacteria are excellent model systems to ident...
ORGANISM(S): Staphylococcus aureus 
2009-11-11 | E-GEOD-15060 | biostudies-arrayexpress
ProteomicsCombining high resolution and exact calibration to boost statistical power: A well-calibrated score function for high-resolution MS2
This project reanalzyes data from 4 other projects. Information about the samples can be found in the following four publications. The four samples used in this study include a ocean metaproteome sample, a human sample, a E. coli sample, and a Plamodium falciparum sample. B. N. Pease, E. L. Huttli...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Escherichia coli 
2018-09-19 | PXD009265 | Pride
E. coli Score function Ocean Human Plasmodium 
TranscriptomicsEffects of dietary curcumin on the colon proteome and transcriptome in the Mdr1a-/- mouse model of inflammatory bowel disease
This study assessed gene expression changes associated with inflammation in the colon tissue of multi-drug resistance targeted mutation (Mdr1a-/-) mice, a model of human IBD. It also tested the anti-inflammatory potential of curcumin in the colon of these mice with a particular focus on the proteome...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61939 | biostudies-arrayexpress
TranscriptomicsModulation of colonic inflammation in Mdr1a-/- mice by green tea polyphenols and their effects on the colon transcriptome and proteome
This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multi-drug resistance targeted mutation (Mdr1a-/-) mouse model of IBD. A colonic histological injury score was determined for each mouse to establish the effect of GrTP on inflamma...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41644 | biostudies-arrayexpress
ProteomicsCoMPaseD - Protease Score Prediction for the Analysis of Small Proteins
In proteome studies, the application of alternative proteases, exclusively or in addition to trypsin, often increases protein sequence or proteome coverage. It has recently been shown that, in particular, the analysis of small proteins benefits from such multi-protease approaches. In the accompanyin...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2026-01-23 | PXD062213 | Pride
Bacillus subtilis Orbitrap elite Alternative proteases Gluc Lysarginase 
UnknownProteome-wide prediction of signal flow direction in protein interaction networks based on interacting domains.
Not available
S-EPMC2742434 | biostudies-literature
TranscriptomicsEffects of dietary curcumin on the colon proteome and transcriptome in the Mdr1a-/- mouse model of inflammatory bowel disease
This study assessed gene expression changes associated with inflammation in the colon tissue of multi-drug resistance targeted mutation (Mdr1a-/-) mice, a model of human IBD. It also tested the anti-inflammatory potential of curcumin in the colon of these mice with a particular focus on the proteome...
ORGANISM(S): Mus musculus 
2014-10-02 | GSE61939 | GEO
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsModulation of colonic inflammation in Mdr1a-/- mice by green tea polyphenols and their effects on the colon transcriptome and proteome
This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multi-drug resistance targeted mutation (Mdr1a-/-) mouse model of IBD. A colonic histological injury score was determined for each mouse to establish the effect of GrTP on inflamma...
ORGANISM(S): Mus musculus 
2012-10-18 | GSE41644 | GEO
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