Sort   by:  
 Page size 
ProteomicsBiopsy proteome score performs well as an effect measure in a gluten-challenge trial of coeliac disease
Objective Development of novel treatments for coeliac disease (CeD) is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardise. Biopsy proteome scoring is an objective alternative to histology which is bas...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD050655 | Pride
Human Proteome score Gut biopsy Evosep Timstofflex Clinical trial 
UnknownCollision cross sections of large positive fullerene molecular ions and their use as ion mobility calibrants in trapped ion mobility mass spectrometry.
Not available
S-EPMC11541393 | biostudies-literature
ProteomicsVARS1 overexpression in hepatocellular carcinoma cell lines
VARS1 was transiently overexpressed in Hep3B and SNU-387 hepatocellular carcinoma-derived cell lines.
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD056392 | Pride
Vars1 Hepatocellular carcinoma Liver 
ProteomicsNewly-Diagnosed Rheumatoid Arthritis Patients have Elevated Levels of Plasma Extracellular Vesicles with Protein Cargo Altered Towards Inflammatory Processes
Extracellular vesicles (EVs) are implicated in rheumatoid arthritis (RA) but have mainly been assessed in RA patients taking disease modifying anti-rheumatic drugs. EVs are nanoparticles important in cell-cell communication and their molecular cargo are biomarker candidates. We characterized the pro...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060460 | Pride
Rheumatoid arthritis Extracellular vesicle Quantitative proteomics 
ProteomicsSpatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment
Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. Th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD062684 | Pride
Mouse Intestine Interferon-gamma Crypt hyperplasia 
ProteomicsBiopsy proteome scoring to determine mucosal remodeling in celiac disease
For celiac disease (CeD) the diagnosis and response to treatment is determined by histological evaluation of gut biopsies which depend on proper biopsy orientation and has poor inter-observer reproducibility. Biopsy proteome measurement that reports on the tissue state can be obtained by mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2024-03-15 | PXD045913 | Pride
Lc-msms Machine learning Molecular histology Clinical proteomics Celiac disease 
Sort   by:  
 Page size