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MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9836 | MetaboLights
ProteomicsLinking post-translational modifications and protein turnover by site-resolved protein turnover (SPOT) profiling
Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labelling and mass spectrometry to measure the turnover of >120,000 peptidoforms including >33,000 phosphorylated, acetylated and u...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD023218 | Pride
Human Ptms Turnover Silac 
ProteomicsAn Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions
Understanding how different mammalian tissues are regulated is central to biology. Since the same proteins often appear in multiple tissues, protein abundance, turnover, and post-translational modifications, like phosphorylation, are key factors that determine tissue-specific proteome properties. Ho...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-11 | PXD055942 | Pride
Brain region Tmtpro Psilac Dia Phosphoproteome Mouse tissue Protein turnover Proteome 
ProteomicsProtein turnover analysis in Salmonella Typhimurium during infection by dynamic SILAC, Topograph and quantitative proteomics
Protein turnover affects protein abundance and phenotypes. Comprehensive investigation of protein turnover dynamics has the potential to provide substantial information about gene expression. Here we report a large-scale protein turnover study in Salmonella Typhimurium during infection by quantitati...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2022-05-17 | PXD033623 | Pride
Proteomics Salmonella typhimurium Dynamic silac Protein turnover 
UnknownCross-species Comparison of Proteome Turnover Kinetics.
Not available
S-EPMC5880112 | biostudies-literature
ProteomicsUbiquitin S65 proteomics: Protein turnover analysis
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002205 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
ProteomicsMammalian Fibroblast Turnover Rates, Protein Abundance, and Protein Damage Response
Within a cell, proteins are in a dynamic state of turnover and are continuously synthesized and degraded. As an energetically expensive cellular process, protein turnover can have two opposing effects on maintaining a healthy proteome during the lifespan of an organism. Rapid protein turnover can re...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-05-07 | PXD018325 | Pride
Mammalian Silac Lfq Primary Ibaq Fibroblast 
UnknownProteome Turnover in the Spotlight: Approaches, Applications, and Perspectives.
Not available
S-EPMC7950106 | biostudies-literature
ProteomicsCircadian regulation of macromolecular complex turnover and proteome renewal
Although costly to maintain, protein homeostasis is indispensable for normal cellular function and long-term health. In mammalian cells and tissues, daily variation in global protein synthesis has been observed, but its utility and consequences for proteome integrity are not fully understood. Usi...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-16 | PXD049176 | Pride
Circardian rhythms Protein homoestasis Psilac_tmt Complex turnover 
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