Proteostasis capacity

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A method to quantitatively measure the proteostasis capacity of cells

Protein homeostasis, or proteostasis, refers to the maintenance of the conformational and functional integrity of the proteome. The term proteostasis therefore encompasses all of the pathways that regulate the synthesis, concentration, folding, trafficking and degradation of proteins. The proteostas...

ORGANISM(S): Mus musculus (Mouse)

2026-02-19 | PXD031826 | Pride

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis.

Not available

S-EPMC6813348 | biostudies-literature

A biosensor-based framework to measure latent proteostasis capacity.

Not available

S-EPMC5773518 | biostudies-literature

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...

ORGANISM(S): Homo sapiens

2016-07-21 | E-GEOD-84636 | biostudies-arrayexpress

Cellular responses in yeast proteostasis mutants affected in diverse branches of the protein quality control system

Protein quality controls (PQC) systems rely on three main activities to prevent the accumulation of misfolded proteins upon stress conditions and aging: refolding, degradation and sequestration. In Saccharomyces cerevisiae the Hsp70 chaperone system plays a central role in protein refolding, while d...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2023-03-10 | PXD037835 | Pride

Chaperone Sequestrases Hsp70 Proteasome Proteostasis

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.

Not available

S-EPMC10939789 | biostudies-literature

Regulation of germline proteostasis by insulin/IGF-1 signaling

PRJNA1078387 | ENA

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

PRJNA780423 | ENA

Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity.

Not available

S-EPMC11336002 | biostudies-literature

Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass

STIM1 is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is indispensable during development, its biological and metabolic functions in mature muscle ...

ORGANISM(S): Mus Musculus (mouse)

2021-12-30 | PXD030674 | JPOST Repository

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