Sort   by:  
 Page size 
TranscriptomicsWhole rye consumption improves blood and liver n-3 fatty acid profile and gut microbiota composition in rats
This study in rats was designed to investigate whether whole rhye (WR) can influence the metabolism of n-3 and n-6 long-chain fatty acids (LCFA) and gut microbiota composition. For 12 weeks, rats were fed a diet containing either 50% WR or 50% refined rye (RR). Total bacterial DNA was extracted from...
ORGANISM(S): uncultured bacterium 
2015-08-06 | E-GEOD-71726 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Caenorhabditis elegans treated with Dichlorvos and fenamiphos, to investigate it as a genomic model for toxicology
Effective toxicological testing of the vast number of new and existing chemicals currently in use will require efficient and cost effective methods. We evaluated the utility of a simple, low cost toxicity testing system employing the nematode Caenorhabditis elegans to identify toxicologically releva...
ORGANISM(S): Caenorhabditis elegans 
2009-06-24 | E-GEOD-12298 | biostudies-arrayexpress
ProteomicsSystems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism
submission for the paper "Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-09 | MSV000084785 | MassIVE
TranscriptomicsGene expression in liver tissue from Ghrh-KO and normal (wild-type) mice
The hypothalamus has recently emerged as a key regulator of metabolism and aging in mammals. We have examined the impact of targeted disruption of hypothalamic hypophysiotropic peptide: Growth Hormone-releasing Hormone (GHRH) in mice on longevity, and the putative mechanisms of delayed aging. GHRH k...
ORGANISM(S): Mus musculus 
2013-11-18 | E-GEOD-51108 | biostudies-arrayexpress
GenomicsGrhl3 is essential for epidermal barrier repair from both physical and immune injury, relevance to lesional skin disease
Epidermal barrier repair mechanisms activated in psoriasis lesions are likely involved in limiting the severity of this disease. We show that loss of grainyhead-like 3 (Grhl3), a pro-terminal differentiation factor in the epidermis, is sufficient to trigger greater sensitivity to and delayed resolut...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-52648 | biostudies-arrayexpress
TranscriptomicsA Whole Transcriptional Linkage Analysis of Gene Co-Regulation in Insecticide Resistant House Flies, Musca domestica
Illumina HiSeq 2000 RNASeq was conducted on the mRNA fraction of three adult female Musca domestica strains. Two strains were the insecticide susceptible strains CS and aabys, which has five distinct recessive morphological markers, one on each of the five autosomes in M. domestica. The third strain...
ORGANISM(S): Musca domestica 
2014-01-02 | E-GEOD-39327 | biostudies-arrayexpress
TranscriptomicsExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Background: Skin aging is associated with intrinsic processes that compromise structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood an...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-35322 | biostudies-arrayexpress
TranscriptomicsAn oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27m3 through the genome [RNA-seq]
B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic EZH2 gain-of-function mutation (Y646F in human, Y641F in the mous...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-79035 | biostudies-arrayexpress
TranscriptomicsResveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...
ORGANISM(S): Mus musculus 
2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
Sort   by:  
 Page size