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ProteomicsProton Transfer Charge Reduction Enables Isobaric Labeling-Based Proteoform Quantification of Overlapping Signals in Top-Down Mass Spectrometry
Top-down mass spectrometry provides a powerful approach for analyzing and quantifying intact proteoforms, i.e., the distinct molecular forms of proteins. Isobaric labeling-based quantification strategies offer the advantages of multiplexing and increased analytical depth. However, a major challenge ...
ORGANISM(S): Bos taurus (Bovine) Gallus gallus (Chicken) 
2026-06-08 | PXD074730 | Pride
Proton transfer charge reduction Top-down proteomics Isobaric labeling Proteoform Quantification 
ProteomicsTop-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction
Here, we present our investigation of the viral proteins of the capsid of adeno-associated viruses via top-down mass spectrometry on the LC timescale. Characterization was improved through the use of proton transfer charge reduction
ORGANISM(S): Human Aav 
2024-06-14 | MSV000095045 | MassIVE
ProteomicsTowards a universal method for middle down analysis of antibodies via proton transfer charge reduction Orbitrap mass spectrometry
We report the development and benchmark of a middle down mass spectrometry strategy based on the combination of different ion fragmentation techniques with proton transfer charge reduction (PTCR) to simplify the gas phase sequencing of mAb subunits. Applied on the liquid chromatography time scale us...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-11 | MSV000095301 | MassIVE
UnknownProton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms.
Not available
S-EPMC7008508 | biostudies-literature
UnknownMass Determination of Filled and Empty AAV5 Particles Enabled by Nanoelectrospray Ionization and Proton Transfer Charge Reduction.
Not available
S-EPMC12823214 | biostudies-literature
UnknownTowards a universal method for middle-down analysis of antibodies via proton transfer charge reduction-Orbitrap mass spectrometry.
Not available
S-EPMC11837950 | biostudies-literature
UnknownProton-coupled electron transfer at a mis-metalated zinc site detected with protein charge ladders.
Not available
S-EPMC11350471 | biostudies-literature
UnknownTop-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction.
Not available
S-EPMC11880350 | biostudies-literature
UnknownEnhanced Payload Localization in Antibody-Drug Conjugates Using a Middle-Down Mass Spectrometry Approach with Proton Transfer Charge Reduction.
Not available
S-EPMC11892948 | biostudies-literature
UnknownNet proton uptake is preceded by multiple proton transfer steps upon electron injection into cytochrome c oxidase.
Not available
S-EPMC3318725 | biostudies-literature
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