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ProteomicsDNA damage stress control is a tLT- and EHMT2-dependent central feature of Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. Merkel cell polyomavirus (MCPyV) is the etiology of 80% of MCC cases via expression of the viral oncogenes small T antigen (sT) and truncated large T antigen (tLT). These proteins impair the Rb1-dependent G1/S check...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD044782 | Pride
Merkel cell carcinoma  truncated lt  ehmt2  proximal interactomics  proteome analysis  dna damage repair signaling. 
UnknownQuantitative Interactomics of Lck-TurboID in Living Human T Cells Unveils T Cell Receptor Stimulation-Induced Proximal Lck Interactors.
Not available
S-EPMC7962135 | biostudies-literature
ProteomicsBoDV-1 phosphoprotein BioID in HEK293
Here we have identified human proteins in spatial proximity (proximal interaction network) of BoDV-1 Phosphoprotein fused to BirA* (E.Coli biotin ligase R118G abortive mutant) at the N-ter and C-ter ends in human cells by proximity-dependent biotinylation (BioID)-based approach. We report 301 high-c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD036750 | Pride
Bioid Bodv-1 Human Phosphoprotein Proximal interactomics 
ProteomicsSARS-CoV-2 proteins BioID in HEK293
SARS-CoV-2 proteins orchestrate complex mechanisms that underlie SARS-CoV-2 infection and COVID-19 causing pathogenic processes. Here we have exhaustively defined human proteins in spatial proximity (proximal interaction network) of 27/28 SARS-CoV-2 proteins in human cells by proximity-dependent bio...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD033452 | Pride
Bioid Human Sars-cov-2 Proximal interactomics 
ProteomicsHPV16 and HPV42 E6 and E7 proximal interactomics
This project identifies molecular mechanisms underlying HPV42-driven transformation.
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD031438 | Pride
Bioid Hpv Human Lc-ms/ms 
ProteomicsQuantitative interactomics of Lck-TurboID in living human T cells unveils T cell receptor stimulation-induced proximal Lck interactors
While Lck has been widely recognized to play a pivotal role in the initiation of the T cell receptor (TCR) signaling pathway, an understanding of the precise regulation of Lck in T cells upon TCR activation remains elusive. Investigation of protein-protein interaction (PPI) using proximity labeling ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-12 | PXD020759 | Pride
Proximity labeling T cell receptor Lck Turboid Interactome 
TranscriptomicsA DNA methylation reader complex that enhances gene transcription
DNA methylation generally functions as a repressive transcriptional signal, but it is also​ ​known to activate gene expression. In either case, the downstream factors remain​ ​largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis​ ​thaliana that associate with meth...
ORGANISM(S): Arabidopsis thaliana 
2018-12-06 | GSE108414 | GEO
UnknownA DNA methylation reader complex that enhances gene transcription.
Not available
S-EPMC6353633 | biostudies-literature
UnknownMapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway.
Not available
S-EPMC10057548 | biostudies-literature
UnknownImpact of High-Fiber or High-Protein Diet on the Capacity of Human Gut Microbiota To Produce Tryptophan Catabolites.
Not available
S-EPMC10176579 | biostudies-literature
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