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GenomicsTFIID enables RNA polymerase II promoter-proximal pausing
TFIID enables RNA polymerase II promoter-proximal pausing
PRJNA548938 | ENA
ProteomicsReduced polymerase pausing compensates for increased chromatin accessibility in the aging liver
Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. However, little is known about the changes on the level of transcriptional regulation. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-15 | PXD034564 | Pride
Tmt Chromating Polymerase Liver Aging 
GenomicsGAGA Factor maintains promoters in nucleosome-free conformation and allows promoter-proximal pausing [MNase]
Promoter-proximal pausing of RNA polymerase II (Pol II) is a widespread in higher eukaryotes. Previous studies have shown that GAF is enriched at paused genes, but the role of GAF in pausing has not been well characterized on a genome-wide level. To investigate the role of GAF in pausing, we RNAi-de...
ORGANISM(S): Drosophila melanogaster 
2015-04-04 | E-GEOD-58956 | biostudies-arrayexpress
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
GenomicsPromoter-proximal pausing mediated by the exon junction complex regulates splicing
Promoter-proximal pausing mediated by the exon junction complex regulates splicing
PRJNA357409 | ENA
GenomicsRegulation of Mammalian Cell Growth and Survival By an RNA Polymerase II-Pausing Factor (ChIP-seq)
Many mammalian genes are occupied by paused RNA polymerase II (pol II) at promoter-proximal regions on both sides of transcription start sites (TSSs). However, the consequences of pol II pausing on gene expression and cell biology are not fully understood. Here we report that genetic ablation of t...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-24113 | biostudies-arrayexpress
GenomicsPAF1, a molecular regulator of promoter-proximal pausing by RNA Polymerase II
PAF1, a molecular regulator of promoter-proximal pausing by RNA Polymerase II
PRJNA288695 | ENA
TranscriptomicsGenome-wide transcriptional profiling of Bacillus subtilis greA deletion and GreA-D44A mutant strains
Bacterial Gre factors associate with RNA polymerase (RNAP) and stimulate intrinsic cleavage of the nascent transcript at the active site of RNAP. Biochemical and genetic studies to date have shown that E. coli Gre factors prevent transcriptional arrest during elongation and enhance transcription fid...
ORGANISM(S): Bacillus subtilis 
2011-04-10 | E-MEXP-3055 | biostudies-arrayexpress
UnknownTFIID Enables RNA Polymerase II Promoter-Proximal Pausing.
Not available
S-EPMC7245555 | biostudies-literature
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