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TranscriptomicsPRPF8 iCLIP on HeLa cells in response to eIF4A3 Knockdown
This experiment uses iCLIP to identify the binding pattern of the spliceosomal protein PRPF8 on RNA. The data shows that PRPF8 binds strongly and specifically in the region 12 to 14nt upstream of 5' splice sites (5ss). Due to PRPF8's role in the formation of the catalytically active spliceosome, thi...
ORGANISM(S): Homo sapiens 
2018-10-14 | E-MTAB-7269 | biostudies-arrayexpress
ProteomicsPRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used patient induced pluripotent stem cells-derived cells, carrying...
ORGANISM(S): Homo sapiens (Human) 
2024-03-01 | PXD043645 | Pride
Splicesome Prpf8 Human Lc-ms/ms 
TranscriptomicsRegulation of constitutive and alternative messenger RNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
RNA-sequencing experiments performed on control siRNA treated and PRPF8 depleted cells
ORGANISM(S): Homo sapiens 
2014-12-31 | E-MTAB-3021 | biostudies-arrayexpress
UnknownPRPF8 is important for BRCA1-mediated homologous recombination.
Not available
S-EPMC5706798 | biostudies-literature
GenomicsPRPF8 iCLIP on HeLa cells in response to eIF4A3 Knockdown
PRPF8 iCLIP on HeLa cells in response to eIF4A3 Knockdown
PRJEB29040 | ENA
TranscriptomicsAnalysis of differential circRNA expression in mouse retina isolated from mice that harbor the Y2334N mutation in both alleles of the pre-mRNA splicing factor PRPF8
The autosomal-dominant Y2334N mutation in PRPF8 is associated with retinitis pigmentosa, a progressive retinal disorder. Here, we investigated how the Y2334N mutation affects circRNA differential expression in the retinas of homozygous Y2334N mutant mice.
ORGANISM(S): Mus musculus 
2026-02-19 | E-MTAB-16570 | biostudies-arrayexpress
UnknownReporting a Homozygous Case of Neurodevelopmental Disorder Associated With a Novel PRPF8 Variant.
Not available
S-EPMC11894437 | biostudies-literature
UnknownVariants in the PRPF8 Gene are Associated with Glaucoma.
Not available
S-EPMC5884903 | biostudies-literature
UnknownPRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing.
Not available
S-EPMC12805961 | biostudies-literature
UnknownPRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.
Not available
S-EPMC9898568 | biostudies-literature
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