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UnknownPRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability.
Not available
S-EPMC9891442 | biostudies-literature
UnknownTargeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis.
Not available
S-EPMC6499697 | biostudies-literature
UnknownPRPS2 enhances RNA m<sup>6</sup>A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms.
Not available
S-EPMC12037730 | biostudies-literature
UnknownStructural basis of human PRPS2 filaments.
Not available
S-EPMC10227994 | biostudies-literature
ProteomicsAffinity purification of PRPS complex in human cultured cells (HEK293T)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD058828 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
ProteomicsAffinity purification of PRPS complex in mouse cultured cells (NIH3T3)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD058829 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
TranscriptomicsPRPS activity governs redox homeostasis in MYC-driven lymphoma
Myc hyperactivation coordinately regulates numerous metabolic processes to drive lymphomagenesis. However, the temporal and epistatic relationships between the medley of pathways, factors, and mechanisms that must functionally cooperate to preserve homeostasis in Myc-overexpressing cells remain larg...
ORGANISM(S): Mus musculus 
2025-02-20 | GSE282435 | GEO
UnknownPhosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis.
Not available
S-EPMC6959080 | biostudies-literature
TranscriptomicsAnti-hyperuricemic Potential of Abietic Acid: Identified from Helianthus annuus L. and Modulate Uric Acid in Human Embryonic Kidney Cells
Sunflower (Helianthus annuus L.) calathide is becoming more well-known as a result of its anti-hyperuricemia bioactivity. Aiming at developing anti-hyperuricemic ingredients in sunflower calathide extract (SCE), we were fortunate to discover abietic acid (AA), identified from SCE, has the capacity t...
ORGANISM(S): Homo sapiens 
2022-03-11 | GSE198133 | GEO
UnknownArginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.
Not available
S-EPMC4503932 | biostudies-literature
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