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ProteomicsAffinity purification of PRPS complex in human cultured cells (HEK293T)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD058828 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
ProteomicsAffinity purification of PRPS complex in mouse cultured cells (NIH3T3)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD058829 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
OtherMultiple signalling pathways converge on UHRF1 stability and activity
Propagation of DNA methylation through cell division relies on the recognition of methylated cytosines by UHRF1. We present an experimental system where regulation of global and site-specific demethylation can be dissected in great detail, which is part of the biology of stem cells transitioning to ...
ORGANISM(S): Mus musculus 
2022-11-18 | GSE158453 | GEO
UnknownEvolutionary origins and innovations sculpting the mammalian PRPS enzyme complex.
Not available
S-EPMC11476008 | biostudies-literature
ProteomicsIdentification of high molecular weight protein/protein complexes in human cultured cells (HEK293T) LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is a highly conserved enzyme that conducts the chokepoint reaction of nucleotide biosynthesis by converting ribose-5-phosphate (R-5-P) to phosphoribosyl pyrophosphate (PRPP). Due to the presence of multiple isoforms and related PRPS-associated proteins ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD059156 | Pride
Prps complex High molecular weight proteins Protein complexes Megadalton assemblies Lc-ms/ms 
UnknownIdentification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma.
Not available
S-EPMC3266911 | biostudies-literature
TranscriptomicsIdentification of novel candidate oncogenes in chromosomal region 17p11.2-p12 in human osteosarcoma
in 25% - 30% of all OS cases the chromosome region 17p11.2-p12 is aberrant. Using SNP array in conjunction with expression microarrays we try to identify genes which can be classified as oncogens or are in someway benificial to the survival of the tumor. To identify minimal significant amplified reg...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-32964 | biostudies-arrayexpress
GenomicsMultiple signalling pathways converge on UHRF1 stability and activity
Multiple signalling pathways converge on UHRF1 stability and activity
PRJNA665250 | ENA
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