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MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
TranscriptomicsTranscriptional response of Pseudomonas aeruginosa PAO1 to human host defense peptide LL-37
In this experiment the transcriptional response of the opportunistic human pathogen Pseudomonas aeruginosa towards physiological concentrations of the major human host defense peptide LL-37 was investigated using microarrays. To this aim, three independent cultures of P. aeruginosa PAO1 were grown u...
ORGANISM(S): Pseudomonas aeruginosa 
2013-12-20 | E-MEXP-3970 | biostudies-arrayexpress
TranscriptomicsResponse of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity
Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety, health and performance of the crewmembers. As a ubiquitous environmental organism that is occasionally part of the human flora, Pseudomonas aeruginosa could pose a health hazar...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2010-07-29 | E-GEOD-16970 | biostudies-arrayexpress
TranscriptomicsGenome wide transcriptional analysis of P. aeruginosa PAO1, response to phosphate limitation
P. aeruginosa PAO1 grown as lawns on Nematode Growth Medium prepared without supplementation (NGM Pi<0.1 mM) has high killing ability against C. elegans, however, no mortality in worms has been observed during 48 hrs when feeding on PAO1 lawns grown on phosphate supplemented full NGM Pi 25 mM, pH 6....
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2011-07-26 | E-GEOD-30967 | biostudies-arrayexpress
no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
ProteomicsProteomics of Pseudomonas aeruginosa PAO1 and PA14
Recent studies have shown that the concentrations of proteins expressed from orthologous genes are often conserved across organisms, and to a greater extent than the abundances of the corresponding mRNAs. However, such studies have not distinguished between evolutionary (e.g., sequence divergence) a...
ORGANISM(S): Pseudomonas Aeruginosa Pa14 (ncbitaxon:652611) Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
2018-08-29 | MSV000082863 | MassIVE
TranscriptomicsTranscription profiling of Dictyostelium discoideum in response to infection with Pseudomonas aeruginosa PA01 and PA14 strains which differ in virulence
Pseudomonas aeruginosa is an opportunistic human pathogen, infecting immuno-compromised patients and causing persistent respiratory infections in people affected from cystic fibrosis. Pseudomonas strain Pseudomonas aeruginosa PA14 shows higher virulence than Pseudomonas aeruginosa PAO1 in a wide ran...
ORGANISM(S): Dictyostelium discoideum 
2008-07-09 | E-TABM-464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa response to low oxygen
In order to understand how Pseudomonas aeruginosa responds to low oxygen we grew strain PAO1 with 3 different oxygen concentrations: 2%, 0.4% and 0% supplemented with nitrate as an electron acceptor. Gene expression under these conditions was compared to that of cells grown with 20% oxygen. Experim...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-15 | E-GEOD-6741 | biostudies-arrayexpress
TranscriptomicsTranscriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen
Characterization of bacterial behavior in the microgravity environment of spaceflight is of importance towards risk assessment and prevention of infectious disease during long-term missions. Further, this research field unveils new insights into connections between low fluid-shear regions encountere...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2011-06-28 | E-GEOD-22684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of P. aeruginosa glutamate mediated biofilm dispersion
Effect of glutamate mediated dispersion of Pseudomonas aeruginosa PAO1 from a biofilm.
ORGANISM(S): Pseudomonas aeruginosa 
2004-07-10 | E-MEXP-87 | biostudies-arrayexpress
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