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TranscriptomicsEither Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis
Stable activation of the WNT signaling effector beta-catenin (CTNNB1(ex3) in ovarian granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life. Loss of the tumor suppressor gene Pten accelerates GCT formation in the CT...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-27656 | biostudies-arrayexpress
TranscriptomicsBiallelic and complicated inactivation of Pten in radiation-induced mouse thymic lymphomas
Inactivation of Pten occurs by multiple mechanisms including epigenetic silencing, point mutations, insertion, and deletion, which are tissue dependent. Although frequent loss of heterozygosity around Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induce...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17751 | biostudies-arrayexpress
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
TranscriptomicsHierarchical synergy of Pten, p53 and Rb pathways in high-grade astrocytoma induced in adult brain
Mutations in the PTEN, TP53 and RB1 pathways are obligate events in the pathogenesis of human glioblastomas, the highest grade of astrocytoma. To investigate synergy between these tumor suppressors in mice, we induced various combinations of compound deletions conditionally in astrocytes and neural ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-22927 | biostudies-arrayexpress
GenomicsPTEN-induced kinase 1 (PINK1) ameliorates autoimmune disease via negative regulation of the STAT3-Th17 axis
PTEN-induced kinase 1 (PINK1) ameliorates autoimmune disease via negative regulation of the STAT3-Th17 axis
PRJNA1068554 | ENA
UnknownPolo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation.
Not available
S-EPMC3195584 | biostudies-literature
UnknownPTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy.
Not available
S-EPMC9198758 | biostudies-literature
TranscriptomicsTranscription profiling of prostate cancer cells with Akt activation
To determine which genes may be regulated by Akt and participate in the transformation of cells, we have examined by microarray analyses genes turned on in the prostate cancer cell line, PC3, when Akt activity was induced. PC3 cells, which lack the lipid phosphatase PTEN, were treated overnight with...
ORGANISM(S): Homo sapiens 
2005-10-11 | E-SMDB-2030 | biostudies-arrayexpress
TranscriptomicsPTEN loss deM-oM-,M-^Anes a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be deM-oM-,M-^Aned by gene expression proM-oM-,M-^Aling. However, even within these deM-oM-,M-^Aned subtypes, heterogeneity prevails. To further elucidate the pathogenesis o...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-45495 | biostudies-arrayexpress
ProteomicsProteome of the cortex of old Pink1-SNCA A53T double mutant Parkinson mice
Parkinson's Disease (PD) is primarily caused by aggregates of alpha synuclein (SNCA) in dopaminergic neurons of the substantia nigra, but PD is a systemic disease and may lead to PD-associated dementia complex. PD-associated encephalopathy is a late manifestation in PD patients at risk for example o...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD039172 | Pride
Lc-ms/ms Mutant alpha synuclein (snca-a53t) Parkinson's disease Pten-induced kinase 1 Pd-associated encephalopathy 
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