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ProteomicsSpecific mixing facilitates the comparative quantification of phosphorylation sites with significant dysregulations
It is still a big challenge to accurately quantify the proteins or proteins PTM sites with extreme relative abundances in comparative protein samples, such as the significantly dysregulated ones. Herein, a novel quantification strategy, Mixing at Specific Ratio (MaSR) before isotope labeling, had be...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) Escherichia coli 
2016-12-06 | PXD005181 | Pride
Lc-msms Mixing at specific ratio Comparative phosphoproteome quantification Stable isotope labeling Extreme relative abundance 
ProteomicsQuantitative Analysis of Global Proteome in human cell line
In total, 5,829 protein groups were identified, among which 4,470 proteins were quantified. The fold-change cutoff was set when proteins with quantitative ratios above 1.3 or below 0.77 are deemed significant. Among the quantified proteins, 12 proteins are up-regulated and 116 proteins are down-regu...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006386 | Pride
Q-exactive Human Proteome 
UnknownQuantitative profiling of PTM stoichiometry by resolvable mass tags.
Not available
S-EPMC9627732 | biostudies-literature
ProteomicsQuantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV by LS-MS/MS
Quantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV(12h) by LS-MS/MS, And lactylation peptides were enriched by Anti-Lactyllysine antibody conjugated agarose beads (PTM-1404, PTM Bio)
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD042171 | Pride
Vsv Quantification Mouse peritoneal macrophages Lactylation Lc-ms/ms 
ProteomicsAn Integrative SP3 Workflow for Multi-PTM Proteomics Profiling
Global proteomic, redox proteomic, and phosphoproteomic data from mouse C10 epithelial cells and skeletal muscle tissue, no treatments used for method development experiments using these biological sytems. Global proteomic, redox proteomic, phosphoproteomic, and acetylomic data from mouse Beta-TC-6 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-06 | MSV000095264 | MassIVE
ProteomicsSystems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation
Chromatin structure and function is maintained by dynamic protein-protein and protein-nucleic acid interactions. Histones are a family of proteins that are abundant chromatin constituents and that carry numerous post-translational modifications (PTMs). Histone PTMs mediate a variety of biological ac...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-16 | PXD002560 | Pride
Post-translational modification  crosstalk  histone  mass spectrometry  proteomics 
ProteomicsAn Integrated Workflow for Analysis of Multiple Protein Post-Translational Modifications
Investigating multiple protein post-translational modifications (PTMs) is critical for unraveling the complexities of protein regulation and the dynamic interplay among PTMs, a growing focus in proteomics. However, simultaneous analysis of diverse PTMs remains a significant technical challenge, as e...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-02-16 | PXD061601 | Pride
Lc-ms/ms Dia Tmt Ptm Pdx Dda 
UnknownqPTM: an updated database for PTM dynamics in human, mouse, rat and yeast.
Not available
S-EPMC9825568 | biostudies-literature
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - angular gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020517 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsA PTM-centric Proteome Informatic Pipeline for Monitoring Post-Translational Modifications by PEIMAN2
Post-translational modifications (PTMs) are under significant focus in molecular biomedicine due to their importance in signal transduction in most cellular and organismal processes. Identification of PTMs, determination of PTM location sites, discrimination between functional and inert PTMs, and qu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD037681 | Pride
Ptm Proteomics Mass spectromtery 
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