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ProteomicsA PTPB1-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway
Protein tyrosine phosphatase 1B (PTP1B) plays a key role in developing different types of cancer. However, the molecular mechanism underlying this effect is unclear. To identify possible molecular targets of PTP1B that mediate its positive role in tumorigenesis, we undertook a SILAC-based phosphopro...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046000 | Pride
Ptpb1 Glioblastoma Cdk3 
GenomicsMus musculus
Ptpb1 iCLIP in 46C mESCs and mNPCs
PRJNA290505 | ENA
OtherPtpb1 iCLIP in 46C mESCs and mNPCs
PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentia...
ORGANISM(S): Mus musculus 
2016-01-01 | GSE71178 | GEO
UnknownIdentification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Not available
S-EPMC5736425 | biostudies-literature
TranscriptomicsPtpb1 iCLIP in 46C mESCs and mNPCs
PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentia...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-71178 | biostudies-arrayexpress
UnknownThe long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas.
Not available
S-EPMC9569026 | biostudies-literature
UnknownPTBP1 mRNA isoforms and regulation of their translation.
Not available
S-EPMC6800477 | biostudies-literature
UnknownNeural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions in AGRN.
Not available
S-EPMC10139058 | biostudies-literature
GenomicsA Functional Network of Gastric-Cancer-Associated Splicing Events Controlled by Dysregulated Splicing Factors
Except for a few genes known to have oncogenic spliceforms in gastric cancer, the full scope of aberrant splicing in gastric oncogenesis remains unclear. In this study, we elucidated the alternative splicing events associated with gastric carcinogenesis and identified upstream regulators governing t...
EGAS00001002256 | EGA
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