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ProteomicsRedox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis
In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-10 | MSV000081708 | MassIVE
ProteomicsThe effects of silencing PTX3 oin the proteome of human endothelial cells
The human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. But PTX3 has also...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036691 | Pride
Endothelial cells Label-free mass spectrometry Ptx3 
GenomicsDifferenatiation of mRNA expression in PTX3-depleted macrophages
Differenatiation of mRNA expression in PTX3-depleted macrophages
PRJNA792950 | ENA
ProteomicsPTX3 structure determination using a hybrid cryo-electron microscopy and AlphaFold approach offers insights into ligand binding and complement activation
Pattern recognition molecules (PRMs) form an important part of innate immunity and respond to infection and damage via triggering processes such as inflammation. The pentraxin family of soluble PRMs comprises long and short pentraxins, with the former containing unique N-terminal regions unrelated t...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034602 | Pride
Ptx3 
GenomicsEffect of PTX3 on gene expression of THP-1 macrophages
Effect of PTX3 on gene expression of THP-1 macrophages
PRJNA944982 | ENA
GenomicsGene expression profiling of TNBC cells engineered to knock-down or overexpress PTX3
Gene expression profiling of TNBC cells engineered to knock-down or overexpress PTX3
PRJNA778246 | ENA
GenomicsMacrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
PRJNA672981 | ENA
TranscriptomicsDifferenatiation of mRNA expression in PTX3-depleted macrophages
PTX3, as the long member of the pentraxin family, is produced mainly by dendritic cells, macrophages, and endothelial cells in response to inflammation. Growing amount of studies suggest that PTX3 can exert potential contradictory roles in inflammation regulation, antimicrobial resistance, and disea...
ORGANISM(S): Homo sapiens 
2023-10-01 | GSE192726 | GEO
GenomicsPOSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]
POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]
PRJNA540670 | ENA
TranscriptomicsEffect of PTX3 on gene expression of THP-1 macrophages
We aimed to investigate the effect of PTX3 on macrophages functions. After PTX3 stimulation for 18 h in THP-1 macrophages, total RNA were harvested for RNA-seq analysis of ctrl (n = 1) and PTX3 group (n = 1).
ORGANISM(S): Homo sapiens 
2023-03-20 | GSE227402 | GEO
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