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TranscriptomicsImpact of ectopic expression of SNAIL2, ZEB2, ZEB1 or TWIST1 on BRAF-target genes in the murine melanocytic melan-a cell line
We have demonstrated that the oncogenic activation of B-RAF (using a truncated delta-BRAF-ER version inducible with tamoxifen) in the melan-a melanocyte cell line triggers the activation of Zeb1 and Twist1 at the expanse of Zeb2 and Snail2. Enforced maintenance of Zeb2 or Snail2 expression reduces t...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-39030 | biostudies-arrayexpress
UnknownA twist for survival and cancer progression.
Not available
S-EPMC2361066 | biostudies-literature
TranscriptomicsRole of iron in the regulation of the epithelial-to-mesenchymal transition (RNA-seq)
The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy1,2. Here, we characterize using RNA sequencing the mRNA levels changes occurring during EMT induced by epidermal growth factor in ...
ORGANISM(S): Homo sapiens 
2019-10-01 | GSE121663 | GEO
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
UnknownLow level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer.
Not available
S-EPMC9092774 | biostudies-literature
ProteomicsCD44 regulates epigenetic plasticity by mediating iron endocytosis - part 2
The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy(1,2). Here, using western blot technique, we show that H3K9me2 decreases when MDA-MB-468 breast cancer cells undergo EMT upon EGF....
ORGANISM(S): Homo sapiens (Human) 
2010-10-09 | PXD012862 | Pride
Emt Ms/ms spectrum Histones Breast cancer 
GenomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (1)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63233 | biostudies-arrayexpress
UnknownHuman telomeric position effect is determined by chromosomal context and telomeric chromatin integrity.
Not available
S-EPMC1307600 | biostudies-literature
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