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TranscriptomicsImpact of ectopic expression of SNAIL2, ZEB2, ZEB1 or TWIST1 on BRAF-target genes in the murine melanocytic melan-a cell line
We have demonstrated that the oncogenic activation of B-RAF (using a truncated delta-BRAF-ER version inducible with tamoxifen) in the melan-a melanocyte cell line triggers the activation of Zeb1 and Twist1 at the expanse of Zeb2 and Snail2. Enforced maintenance of Zeb2 or Snail2 expression reduces t...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-39030 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
GenomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (1)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63233 | biostudies-arrayexpress
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (3)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63235 | biostudies-arrayexpress
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (2)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63234 | biostudies-arrayexpress
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
TranscriptomicsEffect of nutritive conditions, adhesion and EMT on transcriptional profile of HMECs transduced by an oncogene RAS and SNAI1, SNAI2 or SNAI3
Oncogenic stress induces a global disturbance of cellular homeostasis and subsequently triggers the activation of tumour suppressor pathways. Energy capacity loss, redox state imbalance, and biosynthetic deficiency constitute the primary signals activating safeguard mechanisms, culminating in levels...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-56164 | biostudies-arrayexpress
TranscriptomicsGenotyping of human neuroblastic tumor NB99
The genetic aberrations of NB tumor NB99 were determined using the Affymetrix SNP chip 50K array (Hind III). Experiment Overall Design: DNA copy number change of NB tumor NB99
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12461 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastic tumors
The expression profiles of 64 neuroblastic tumors (mainly neuroblastoma) were determined on Affymetrix chips HG U133 Plus 2.0. Experiment Overall Design: 64 neuroblastic tumors
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12460 | biostudies-arrayexpress
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