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ProteomicsDUSP8 dephosphorylates Pur-alpha
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044898 | Pride
Pur-alpha In vitro phosphatase assay Dusp8 
TranscriptomicsDme Pur-alpha RIP-Chip
ovary extracts from transgenic flies expressing either GFP alone or a GFP-Pur-alpha fusion protein were prepared and anti-GFP immpunoprecipitates were made. RNA was isolated from the input and bound fractions and analyzed using Affymetrix drosophila 2.0 arrays
ORGANISM(S): Drosophila melanogaster 
2012-03-01 | E-MEXP-3546 | biostudies-arrayexpress
ProteomicsDUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044824 | Pride
Asthma Pur-α Il-9 Th9 Dusp8 Atopic dermatitis 
ProteomicsDUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044818 | Pride
Asthma Pur-α Il-9 Th9 Dusp8 Atopic dermatitis 
UnknownPur-alpha functionally interacts with FUS carrying ALS-associated mutations.
Not available
S-EPMC4632316 | biostudies-literature
UnknownPur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Not available
S-EPMC4791193 | biostudies-literature
UnknownCircular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-α activity.
Not available
S-EPMC8817017 | biostudies-literature
UnknownX-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface.
Not available
S-EPMC2765457 | biostudies-literature
UnknownStructural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
Not available
S-EPMC4764581 | biostudies-literature
UnknownPur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells.
Not available
S-EPMC4892494 | biostudies-literature
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