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ProteomicsDUSP8 dephosphorylates Pur-alpha
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044898 | Pride
Pur-alpha In vitro phosphatase assay Dusp8 
ProteomicsDUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044818 | Pride
Asthma Pur-α Il-9 Th9 Dusp8 Atopic dermatitis 
ProteomicsType 2 diabetes risk gene Dusp8 is a gatekeeper for hypothalamic Jnk signaling and insulin sensitivity
Recent genome-wide association studies (GWAS) identified Dusp8, a dual-specificity phosphatase targeting MAP kinases, as type 2 diabetes risk gene. Here, we unravel Dusp8 as gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male but not female Dusp8 loss-of-function m...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-17 | PXD019451 | Pride
Leptin Jnk Type2 diabetes Dusp8 
GenomicsType 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
PRJNA448745 | ENA
TranscriptomicsType 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
Recent genome-wide association studies (GWAS) identified DUSP8, a dual-specificity phosphatase targeting MAP kinases, as type 2 diabetes (T2D) risk gene. Here, we unravel Dusp8 as gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male but not female Dusp8 loss-of-func...
ORGANISM(S): Mus musculus 
2020-08-26 | GSE112688 | GEO
ProteomicsDUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α
Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T-cell-specific DUSP8 conditional knockout (T-DUSP8 cKO) mice, mass spectrometry analy...
ORGANISM(S): Homo sapiens (Human) 
2023-09-30 | PXD044824 | Pride
Asthma Pur-α Il-9 Th9 Dusp8 Atopic dermatitis 
UnknownDusp8 affects hippocampal size and behavior in mice and humans.
Not available
S-EPMC6925303 | biostudies-literature
UnknownmiR-147b mediated suppression of DUSP8 promotes lung cancer progression.
Not available
S-EPMC11014796 | biostudies-literature
UnknownDUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.
Not available
S-EPMC4938738 | biostudies-literature
UnknownDUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization.
Not available
S-EPMC12486788 | biostudies-literature
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