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MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownCorrection: SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.
Not available
S-EPMC8664222 | biostudies-literature
TranscriptomicsRole of Humoral Immunity against Hepatitis B Virus Core Antigen in the Pathogenesis of Acute Liver Failure
To investigate the role of viral and host factors in acute liver failure, we analyzed serum and multiple liver specimens obtained at the time of liver transplantation from four well-characterized patients. We carried out an integrated clinicopathological analysis, gene and microRNA expression profil...
ORGANISM(S): Homo sapiens 
2018-10-29 | E-GEOD-96851 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsMetabolomics profiling of pre-and post-anesthesia plasma samples obtained via Ficoll separation
1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the metabolic consequences of general anesthesia in the plasma of two groups of patients with diagnosis for non-metastatic colorectal cancer and metastatic colorectal cancer with liver-metastasis, respectively. Patients were tr...
2015-11-17 | MTBLS172 | MetaboLights
TranscriptomicsRNA-seq of a controlled porcine model of trauma and haemorrhagic shock treated by fluid resuscitation against untreated controls
This was a randomised study in terminally anaesthetised female cross-bred Large White pigs. Initially, animals were anaesthetised and instrumented for continuous physiological monitoring and sampling; blood samples were collected upon initiation of the surgery (line-in, T = -150 minutes). Following ...
ORGANISM(S): Sus scrofa 
2026-10-28 | E-MTAB-16011 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human trauma patients with and without haemorrhagic shock
Patients were recruited between February 2008 and March 2019 through the Activation of Coagulation and Inflammation in Trauma (ACIT-II) study, a prospective platform cohort study evaluating aspects of coagulation and inflammation in trauma patients (NHS REC: 07/Q0603/20). Patients at the Royal Londo...
ORGANISM(S): Homo sapiens 
2026-10-29 | E-MTAB-16212 | biostudies-arrayexpress
UnknownSexual abstinence and other behaviours immediately following a new STI diagnosis among STI clinic patients: Findings from the Safe in the City trial.
Not available
S-EPMC9346433 | biostudies-literature
TranscriptomicsSingle cell RNA-seq of human CD8+ T cells binding the IAV HLA-A24/PB1 498-505 tetramer
PBMCs from 4 donors were stained with the influenza A virus HLA-A24/PB1 498-505 tetramer. Two donors (non-LIFT8 and non-LIFT12) showed TCR independent KIR binding to tetramers whereas the other two donors (Non-LIFT14 and Non-LIFT10) showed TCR specific binding. Cells were single-cell sorted on a BD ...
ORGANISM(S): Homo sapiens 
2021-04-08 | E-MTAB-10109 | biostudies-arrayexpress
UnknownRare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.
Not available
S-EPMC6689268 | biostudies-literature
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