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MetabolomicsPFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. To date, research on the direct interactions betwe...

2025-07-08 | MTBLS12688 | MetaboLights
MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
GenomicsFolate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
PRJNA1026611 | ENA
TranscriptomicsDe Novo Purine Synthesis Mediates Circadian Control of Cell Cycle in Zebrafish (array)
Cell cycle and metabolism are two major outputs controlled by circadian rhythm in many organisms. Here we show that the three processes were linked through inosine 5'-phosphate dehydrogenase (impdh), a rate-limiting enzyme in de novo purine synthesis. We using adult zebrafish as a model system,we ap...
ORGANISM(S): Danio rerio 
2013-10-01 | E-GEOD-51277 | biostudies-arrayexpress
TranscriptomicsDe Novo Purine Synthesis Mediates Circadian Control of Cell Cycle in Zebrafish (array)
Cell cycle and metabolism are two major outputs controlled by circadian rhythm in many organisms. Here we show that the three processes were linked through inosine 5'-phosphate dehydrogenase (impdh), a rate-limiting enzyme in de novo purine synthesis. We using adult zebrafish as a model system,we ap...
ORGANISM(S): Danio rerio 
2013-10-01 | GSE51277 | GEO
UnknownSuccinate dehydrogenase activity supports de novo purine synthesis.
Not available
S-EPMC11888382 | biostudies-literature
UnknownA non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.
Not available
S-EPMC7618541 | biostudies-literature
UnknownATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease.
Not available
S-EPMC9643655 | biostudies-literature
UnknownERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Not available
S-EPMC7306006 | biostudies-literature
UnknownPathway engineered enzymatic de novo purine nucleotide synthesis.
Not available
S-EPMC2746247 | biostudies-literature
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