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MetabolomicsIntegrated Multi-omics Elucidation of the Uric Acid Degradation Pathway in Limosilactobacillus fermentum M5e

Hyperuricemia is a growing global health concern associated with gout, renal diseases, and cardiovascular disorders. Current pharmacotherapies are often limited by side effects, underscoring the need for alternative strategies. In this study, we isolated Limosilactobacillus fermentum M5...

2026-01-26 | MTBLS13223 | MetaboLights
MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
MetabolomicsUnveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights
TranscriptomicsThe purine metabolite allantoin enhances abiotic stress tolerance through synergistic activation of abscisic acid metabolism
Purine catabolism is regarded as a housekeeping function that remobilizes nitrogen for plant growth and development. However, emerging evidence suggests that certain purine metabolites might contribute to stress protection of plants. Here, we show that in Arabidopsis, the intermediary metabolite all...
ORGANISM(S): Arabidopsis thaliana 
2014-01-16 | E-GEOD-44922 | biostudies-arrayexpress
TranscriptomicsLMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells
[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-20211 | biostudies-arrayexpress
UnknownDegradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity.
Not available
S-EPMC5985227 | biostudies-literature
MetabolomicsOrganic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined
Small metabolites and peptides in 17 snake venoms (Elapidae, Viperinae, and Crotalinae), were quantified using liquid chromatography-mass spectrometry. Each venom contains >900 metabolites and peptides. Many small organic compounds are present at levels that are probably significant in prey envenoma...
2023-01-11 | MTBLS755 | MetaboLights
GenomicsDysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [ATAC-seq]
Dysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [ATAC-seq]
PRJNA1047587 | ENA
GenomicsDysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [RNA-seq]
Dysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [RNA-seq]
PRJNA1047590 | ENA
GenomicsDysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [ChIP-seq]
Dysregulated purine metabolism in DIPG reveals new treatment strategies with old drugs [ChIP-seq]
PRJNA1047588 | ENA
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