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ProteomicsExtracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture
A multibillion dollar pharmaceutical industry targets purinergic signaling pathways in humans. However, in contrast, little is known about purinergic signaling in plants. Extracellular adenosine-5’-triphosphate (eATP) acts as a damage-associated molecular pattern (DAMP) in both animals and plants. T...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-10-24 | PXD006678 | Pride
Plant Purinoceptors kinase Purinergic signaling Phosphorylation 
TranscriptomicsATP effect on Arabidopsis roots
Extracellular adenosine 5’-triphosphate (ATP) is a signaling molecule. To define the global transcriptional response to ATP, we performed DNA microarray analysis using RNA derived from wild-type (Col-0) Arabidopsis and the dorn1-1 mutant, Lectin receptor kinase I.9 (At5g60300) carrying a EMS point m...
ORGANISM(S): Arabidopsis thaliana 
2014-01-27 | E-GEOD-52610 | biostudies-arrayexpress
ProteomicsAnalysis of protein phosphorylation in response to the ATP treatment in Arabidopsis thaliana
The project intended to reveal protein phosphorylation patterns in Arabidopsis thaliana in response to ATP. For this purpose, Arabidopsis thaliana plants, including WT, ATP receptor mutants (p2k1, p2k2, and double mutant p2k1/p2k2), and P2K1 overexpression plants, were treated with ATP or buffer (as...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
MSV000095888 | MassIVE
TranscriptomicsExpression data from mouse bone marrow-derived macrophages (BMDMs)
To recruit phagocytes, apoptotic cells characteristically release ATP, which functions as a “danger” signal. Here, we found that the culture supernatant of apoptotic cells activated the macrophages to express anti-inflammatory genes such as NR4A and Thbs1. A high level of AMP accumulated in the apop...
ORGANISM(S): Mus musculus 
2014-06-24 | E-GEOD-50883 | biostudies-arrayexpress
UnknownRelative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression.
Not available
S-EPMC5091293 | biostudies-literature
UnknownAβ1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes.
Not available
S-EPMC11071907 | biostudies-literature
UnknownP2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy.
Not available
S-EPMC8777980 | biostudies-literature
TranscriptomicsExpression data from of HD-iPSC and CON-iPSC neuron derivatives
Compared the global gene expression profiles of HD- and CON-iPSC-derived neurons We used microarrays to detail the global programme of gene expression for comparing the global gene expression profiles of HD- and CON-iPSC-derived neurons and facilitating studies of medium spiny neurons (MSN)-degenera...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-59051 | biostudies-arrayexpress
TranscriptomicsExpression data from HMC-1 mast cells
We demonstrate that the G protein Gi3 is the cellular target of the adenosine A3 receptor (A3R). By using a cell permeable peptide comprising the C-terminal end of Gαi3 fused to an importation sequence (ALL1) as a selective inhibitor of Gi3 signaling, we show that by coupling to Gi3, the A3R stimu...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19888 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Adenosine receptor (AdoR) null mutant in Drosophila melanogaster imagoes
Dysregulation of adenosine (Ado) homeostasis has been observed in both rodent models and human patients of Huntington’s disease (HD). However, the underlying mechanisms of Ado signaling in HD pathogenesis is still unclear. In this study we examined influence of Ado signaling on Drosophila HD model. ...
ORGANISM(S): Drosophila melanogaster 
2020-10-17 | E-MTAB-8704 | biostudies-arrayexpress
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