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Chromatin structure and function is regulated by reader proteins recognizing histone modifications and/or histone variants. We recently identified PWWP2A as a binder for H2A.Z-containing nucleosomes (Pünzeler, S. et al., EMBO J 2017). Here, as part of a larger project trying to characterize PWWP2A, ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-30 | PXD010202 | Pride
Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-07-19 | PXD010445 | Pride
Chromatin structure and function is regulated by reader proteins recognizing histone modifications and/or histone variants. We recently identified PWWP2A, which tightly binds to H2A.Z-containing nucleosomes and is involved in mitotic progression and cranial-facial development. Here, using in vitro a...
ORGANISM(S): Homo sapiens (Human) 
2018-08-27 | PXD010424 | Pride
Nascent transcription of E14, PWWP2AKO, and PWWP2A/B DKO
PWWP2A variant NuRD complex represses intragenic spurious transcription initiation
Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, h...
ORGANISM(S): Mus musculus 
2018-07-20 | GSE112112 | GEO
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