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ProteomicsSynaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons - second data set
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. The morphology, connectivity, electrophysiological properties, and role in behavior of these neurons have been extensively analyzed. However, the molecular composi...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD052081 | Pride
Neurons Synapses 
GenomicsPyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
PRJNA1138229 | ENA
ProteomicsCortical layer 5 neuron-specific synaptic protein profiling suggests differential vulnerability to neurodevelopmental disorders
Pyramidal neurons in the cortex are embedded in distinct information processing pathways. Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons receive different input and project to distinct brain regions. The synaptic molecular signatures that define synaptic connectivity ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD046812 | Pride
Synaptic proteome Neurodevelopment Turboid 
UnknownReduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.
Not available
S-EPMC10446482 | biostudies-literature
UnknownFrom Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex.
Not available
S-EPMC11456696 | biostudies-literature
TranscriptomicsDeep sequencing reveals cell-type specific patterns of single cell transcriptome variation
We present high quality deep read-depth single cell RNA sequencing for 91 cells from five mouse tissues and 18 cells from two rat tissues, along with 30 control samples of bulk RNA diluted to single-cell levels. We find that transcriptomes differ globally across tissues with regard to the number of ...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-56638 | biostudies-arrayexpress
UnknownPyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons.
Not available
S-EPMC8827762 | biostudies-literature
UnknownRelationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons.
Not available
S-EPMC5636900 | biostudies-literature
TranscriptomicsPyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own research, have shown that specific interneuron subtypes are closely associated with particular pyramidal ne...
ORGANISM(S): Mus musculus 
2024-08-15 | GSE272706 | GEO
UnknownScn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons.
Not available
S-EPMC10205085 | biostudies-literature
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