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ProteomicsMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in numerous essential cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. This ...
ORGANISM(S): Staphylococcus aureus 
2018-10-17 | PXD006483 | Pride
Pyridoxal phosphate Cofactor Vitamin b6 
ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
ProteomicsTailored pyridoxal probes unravel novel cofactor-dependent targets and antibiotic hits in critical bacterial pathogens
Unprecedented bacterial targets are urgently needed for the development of novel antibiotics to overcome the current resistance crisis. Challenges include the limited uptake of compounds as well as prioritizing proteins for their druggability and functional relevance. Especially, the wealth of uncha...
ORGANISM(S): Pseudomonas aeruginosa Escherichia coli Staphylococcus aureus 
2022-08-12 | PXD029832 | Pride
Enzyme characterization Antibiotic compound screening Chemical proteomics Pyridoxal phosphate dependent enzymes 
UnknownA genomic overview of pyridoxal-phosphate-dependent enzymes.
Not available
S-EPMC1326353 | biostudies-literature
UnknownMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics.
Not available
S-EPMC6252082 | biostudies-literature
UnknownMolecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome.
Not available
S-EPMC4116655 | biostudies-literature
UnknownCurrent Advances on Structure-Function Relationships of Pyridoxal 5'-Phosphate-Dependent Enzymes.
Not available
S-EPMC6411801 | biostudies-literature
UnknownMechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.
Not available
S-EPMC5025676 | biostudies-literature
UnknownThe Pyridoxal-5'-Phosphate-Dependent Enzymes of <i>Mycobacterium tuberculosis</i>.
Not available
S-EPMC12910592 | biostudies-literature
ProteomicsSLC25A38 is Required for Mitochondrial Pyridoxal 5’-Phosphate (PLP) accumulation
Many essential proteins require pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, as a cofactor for activity including enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mammalian PLP-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058312 | Pride
Slc25a38 Mito ip Proliferation defects Lc-ms/ms 
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