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MetabolomicsUninfected Macaca mulatta exposed to pyrimethamine to produce and integrate clinical, hematological, and omics control measures.
Not available
ORGANISM(S): Macaca mulatta 
ST000592 | MetabolomicsWorkbench
ProteomicsMolecular markers of adaptive responses in Toxoplasma gondii to Pyrimethamine treatment
In this study, we employed bio-orthogonal non-canonical amino acid tagging (BONCAT) combined with iTRAQ-based quantitative proteomics to investigate the effects of pyrimethamine (PM) on newly synthesised proteins (NSPs) in Toxoplasma gondii. Parasites were treated with varying concentrations of PM, ...
ORGANISM(S): Toxoplasma gondii 
2025-05-07 | PXD054994 | Pride
Boncat Pyrimethamine Toxoplasma gondii Quantitative proteomics Itraq 
TranscriptomicsMicroarray analysis of murine kidney treated with Amodiaquine and Sulfodoxine-Pyrimethamine
Differential gene expression in mice kidney after Amodiaquine and Sulfodoxine-Pyrimethamine anti-malaria treatments were evaluated. Dosages were decided based on standard malaria therapy in human. Mice (Mus musculus) belonging to control and Amodiaquine and Sulfodoxine-Pyrimethamine administered gro...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-19157 | biostudies-arrayexpress
GenomicsTo investigate the effects of NRF2 inhibitors (pyrimethamine) on mRNA expression in mouse esophageal epithelium.
To investigate the effects of NRF2 inhibitors (pyrimethamine) on mRNA expression in mouse esophageal epithelium.
PRJNA986505 | ENA
TranscriptomicsMicroarray analysis of murine kidney treated with Amodiaquine and Sulfodoxine-Pyrimethamine
Differential gene expression in mice kidney after Amodiaquine and Sulfodoxine-Pyrimethamine anti-malaria treatments were evaluated. Dosages were decided based on standard malaria therapy in human.
ORGANISM(S): Mus musculus 
2014-12-23 | GSE19157 | GEO
TranscriptomicsTo investigate the effects of NRF2 inhibitors (pyrimethamine) on mRNA expression in mouse esophageal epithelium.
To study the effects of NRF2 inhibitors (pyrimethamine) on mRNA expression in mouse esophageal epithelium.
ORGANISM(S): Mus musculus 
2023-10-12 | GSE235584 | GEO
TranscriptomicsMalaria Host Pathogen Interaction Center: Gene and exon transcript abundances of uninfected Macaca mulatta treated with pyrimethamine over 7 time points in a 100 day study
The Malaria Host-Pathogen Interaction Center (MaHPIC) is an inter-disciplinary NIH systems biology contract that utilizes multiple omics types (omics, clinical, and mathematical models), to iteratively test and develop hypotheses related to the complex host-parasite dynamics in the course of malari...
ORGANISM(S): Macaca mulatta 
2014-10-10 | E-GEOD-58340 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis of Mice liver treated with Amodiaquine and Sulfodoxine-Pyrimethamine
The study describes the differential gene expression analysis in murine liver following dosing with human therapeutic equivalent doses of Amodiaquine and Sulfodoxine-Pyrimethamine antimalarial drugs.The dosing was decided based on standard antimalarial therapy.
ORGANISM(S): Mus musculus 
2011-06-21 | GSE17392 | GEO
GenomicsTo investigate the effects of NRF2 inhibitors (pyrimethamine and mitoxantrone) on gene expression in a human esophageal squamous cell carcinoma cell line (KYSE70)
To investigate the effects of NRF2 inhibitors (pyrimethamine and mitoxantrone) on gene expression in a human esophageal squamous cell carcinoma cell line (KYSE70)
PRJNA724017 | ENA
GenomicsTo investigate the effects of NRF2 inhibitors (pyrimethamine and mitoxantrone) on mRNA expression in a human esophageal squamous cell carcinoma cell line (KYSE70 cells)
To investigate the effects of NRF2 inhibitors (pyrimethamine and mitoxantrone) on mRNA expression in a human esophageal squamous cell carcinoma cell line (KYSE70 cells)
PRJNA986507 | ENA
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