The complete pool of barcoded homozygous and essential heterozygous diploid deletion strains of S. cerevisiae were screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound.
Hermansen2015 - denovo biosynthesis of pyrimidines in yeast
This model is described in the article:
Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.
Hermansen RA , Mannakee BK , Knech...