Pyruvate carboxylase

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Unknown (420)
Transcriptomics (55)
Genomics (43)
Proteomics (22)
Metabolomics (14)
Models (5)
Methylation profiling (1)

Organisms

Mus musculus (19)
Homo sapiens (18)
Mycobacterium tuberculosis SP7 (15)
Mycobacterium tuberculosis SP10 (15)
Mycobacterium tuberculosis SP13 (15)
Mycobacterium tuberculosis SP22 (15)
Chlamydomonas reinhardtii (15)
Enterococcus mundtii CRL35 (15)
Oncorhynchus tshawytscha (15)
Pseudomonas canadensis (15)
Pseudomonas aeruginosa PAO1H2O (15)
Bacillus subtilis subsp. subtilis str. 168 (6)
Saccharomyces cerevisiae (3)
Rattus norvegicus (3)
Listeria monocytogenes (2)
Arabidopsis thaliana (2)
Corynebacterium glutamicum ATCC 13032 (2)
Corynebacterium glutamicum (2)
Bacillus subtilis (2)
cellular organisms (2)
Oryza sativa Japonica Group (1)
Streptococcus pneumoniae R6 (1)
Actinoplanes (1)
Gluconobacter oxydans (1)
Komagataella pastoris (1)
Rattus (1)
Pseudomonas putida KT2440 (1)
Escherichia coli (1)
Macaca mulatta (1)
Zea mays (1)

Organisms

Mus musculus (13)
Homo sapiens (6)
Corynebacterium glutamicum ATCC 13032 (2)
Bacillus subtilis subsp. subtilis str. 168 (2)
Streptococcus pneumoniae R6 (1)
Komagataella pastoris (1)
Actinoplanes (1)
Lactobacillus delbrueckii subsp. bulgaricus (1)
Listeria monocytogenes (1)
Arabidopsis thaliana (1)
Rattus norvegicus (1)
Saccharomyces cerevisiae (1)

Repository

ENA (41)
geo (30)
biostudies-arrayexpress (26)
pride (15)
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FAIRDOMHub (1)

Tissue

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Blood cell (1)
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Cell culture (1)

Disease

Diabetes mellitus (2)
Cervix carcinoma (1)
Disease free (1)
Acute leukemia (1)

Technology Type

Mass Spectrometry (15)
Mass spectrometry (9)
Shotgun proteomics (9)
Mass spectrometry assay (5)
Data-dependent acquisition (2)
Bottom-up proteomics (2)
HDMSE (1)
SWATH MS (1)
Data-independent acquisition (1)
Affinity purification coupled with mass spectrometry proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (5)
Liquid Chromatography MS - negative - hilic (4)
Liquid Chromatography MS - negative - reverse phase (4)
Illumina HiSeq 2500 (3)
Liquid Chromatography MS - alternating - hilic (3)
Liquid Chromatography MS - positive - hilic (3)
Liquid Chromatography MS - positive - reverse phase (3)
Liquid Chromatography MS - negative - reverse-phase (2)
GeneChip Scanner 3000 [Affymetrix] (1)
MinION (1)
BGISEQ-500 (1)
NextSeq 500 (1)
TripleTOF 5600 (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
Q Exactive (1)
Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - positive - reverse-phase (1)

Publication Date

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2019 (3)
2014 (3)
2005 (2)
2012 (2)
2010 (2)
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2013 (1)

UNIPROT ID/AC

P10515 (2)
P01275 (2)
Q96G03 (2)
P54840 (2)
Q16822 (2)
Q15181 (2)
P17858 (2)
P35557 (2)
O75390 (2)
P11168 (2)
P16118 (2)
P05062 (2)
P00338 (2)
P07195 (2)
O00330 (2)
P09622 (2)
P07864 (2)
P04406 (2)
P01308 (2)
P30613 (2)
P36871 (2)
P06744 (2)
P06733 (2)
P09104 (2)
P13929 (2)
O00757 (2)
P09467 (2)
P35575 (2)
P35558 (2)
Q16851 (2)

CHEBI ID

CHEBI:30769 (5)
CHEBI:32816 (5)
CHEBI:16908 (5)
CHEBI:44897 (4)
CHEBI:4170 (4)
CHEBI:4167 (4)
CHEBI:15713 (4)
CHEBI:15351 (4)
CHEBI:17552 (4)
CHEBI:16027 (4)
CHEBI:15422 (4)
CHEBI:16761 (4)
CHEBI:17835 (3)
CHEBI:18357 (2)
CHEBI:422 (2)
CHEBI:30744 (2)
CHEBI:16077 (2)
CHEBI:28087 (2)
CHEBI:15377 (2)
CHEBI:24636 (2)
CHEBI:15346 (2)
CHEBI:29052 (2)
CHEBI:17659 (2)
CHEBI:18066 (2)
CHEBI:15996 (2)
CHEBI:28602 (2)
CHEBI:17794 (2)
CHEBI:16001 (2)
CHEBI:16905 (2)
CHEBI:16526 (2)

Metabolite Name

Lactate (6)
Serine (6)
Adenosine (6)
Dodecanoic acid (6)
Pyruvate (6)
Aminocyclopyrachlor (5)
Leucine (5)
O-Acetylserine (5)
Fumaric acid (5)
Taurine (5)
1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol (5)
5-Aminolevulinic acid (5)
4-Oxohexanoic acid (5)
Glyceric acid (5)
Glycylleucine (5)
Malic acid (5)
Ala-Gly (5)
Asparagine (5)
Fructose (5)
Phe-Val (5)
Pyruvaldehyde (5)
Glutamine (5)
Myristic acid (5)
Gamma-Glutamylglutamine (4)
UDP-N-acetylglucosamine (4)
Glutamate (4)
Norleucine (4)
Galactose (4)
2-Hydroxyhexanoic acid (4)
Caplamin (4)

First Public Date

2025 (8)
2023 (8)
2026 (5)
2024 (5)
2014 (5)
2021 (3)
2022 (2)
2019 (2)
2018 (2)
2020 (1)

Modelling Approach

Ordinary differential equation model (2)
Constraint-based model (2)

Lab affiliation

The Scripps Research Institute (2)
Departments of Biological Chemistry & Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore, MD (1)
Forschungszentrum Juelich GmbH Institute of Bio- and Geosciences 1 Systems Biotechnology Group: Quantitative Microbial Phenotyping (1)
Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden. (1)
Department of Biosciences and Nutrition, Karolinska Institutet (1)
Institut of Fundamental Neuroscience Federal Center of Brain Research and Neurotechnologies Ostrovityanova 1/10 117513 Moscow Russia (1)
Rappleye Lab, Department of Microbiology, Ohio State University, United States (1)
Head, Department of Anthropology, AISS Amity University Uttar Pradesh Sector-125, Noida (1)
KU Leuven-VIB Center for Cancer Biology (1)
Department of Immunobiology, University of Lausanne (Chemin des Boveresses 155, Epalinges 1066) (1)
Department of Chemistry, University of California, Riverside, CA92521-0403, USA. (1)
Laboratório de Biotecnologia, Centro de Biociências e Biotecnologia (CBB), Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Av. Alberto Lamego, Campos dos Goytacazes, RJ, Brazil. Unidade de Biologia Integrativa, Setor de Genômica e Proteômica, UENF, Campos dos Goytacazes, RJ, Brazil. (1)
James McGill Professor Director and CEO, BioFuelNet Canada Director, McGill Network for Innovation in Biofuels and Bioproducts Director, Eastern Canadian Oilseeds Development Initiative Plant Science Department, McGill University 21111 Lakeshore Road Ste. Anne de Bellevue, Quebec Canada H9X3V9 (1)
James McGill Professor Director and CEO, BioFuelNet Canada Director, McGill Network for Innovation in Biofuels and Bioproducts Director, Eastern Canadian Oilseeds Development Initiative Plant Science Department, McGill University 21111 Lakeshore Road Ste. Anne de Bellevue, Quebec Canada H9X3V9 Phone: +1 514 398 7866 Fax: +1 514 398 7990 Website: www.mcgill.ca/plant/faculty/smith/ (1)

IsPrivate

False (4)

Model Flag

Non Kinetic (2)

Submitter Keywords

FROG (2)

Classification

bacteria (4)

Study type

Transcription profiling by array (15)
RNA-seq of coding RNA (9)
Cell line - High-throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2022 (47)
2021 (38)
2023 (34)
2019 (34)
2024 (32)
2025 (32)
2020 (25)
2017 (24)
2018 (22)
2014 (18)
2013 (17)
2008 (16)
2015 (16)
2012 (15)
2011 (14)
2010 (12)
2009 (10)
2016 (9)
2007 (6)
2026 (5)
2004 (4)
2006 (3)
2000 (3)
2005 (2)
2003 (2)
2001 (2)
1998 (1)
1995 (1)
1973 (1)
1970 (1)

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Pyruvate carboxylase and carbon metabolism in Listeria monocytogenes

Transcriptional profile of wild type L. monocytogenes (EGDe) and a pycA mutant strain was compared on growth in BHI. The human pathogen L. monocytogenes is a facultatively intracellular bacterium that survives and replicates in the cytosol of many mammalian cells. The listerial metabolism, especia...

ORGANISM(S): Listeria monocytogenes

2010-02-09 | E-GEOD-19014 | biostudies-arrayexpress

Catabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein under biotin- and pyruvate carboxylase-deficient conditions in Pichia pastoris

We have identified a methanol- and biotin-starvation-inducible zinc finger protein named ROP [repressor of phosphoenolpyruvate carboxykinase (PEPCK)] in the methylotrophic yeast Pichia pastoris. When P.pastoris strain GS115 (wild-type, WT) is cultured in biotin-deficient, glucose ammonium (Bio-) ...

ORGANISM(S): Pichia pastoris

2011-10-13 | E-GEOD-32948 | biostudies-arrayexpress

Requirement of hepatic pyruvate carboxylase during fasting, high fat and ketogenic diet

Pyruvate has two major fates upon entry into mitochondria, the oxidative decarboxylation to acetyl-CoA or the biotin-dependent carboxylation to oxaloacetate via pyruvate carboxylase (Pcx). Here we have generated mice with a liver specific knockout of pyruvate carboxylase (PcxL-/-) to understand the...

ORGANISM(S): Mus musculus (Mouse)

2022-10-31 | PXD032028 | Pride

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in governing metabolic homeostasis is less understood. Here, we describe a human adipocyte-specific lncRNA, ADIPINT, that regulates pyruvate carboxylase , a pivotal enzyme in energy metabolism. With a novel app...

ORGANISM(S): Homo sapiens (Human)

2022-06-09 | PXD032769 | Pride

Human adipocyte troops rna-interaction pyruvate carboxylase metabolism

suppression of Pyruvate carboxylase

PRJNA821599 | ENA

suppression of Pyruvate carboxylase in M-wnt tumors

PRJNA821609 | ENA

suppression of Pyruvate carboxylase in E0771 cells [in vitro]

PRJNA821607 | ENA

suppression of Pyruvate carboxylase in E0771 tumors [in vivo]

PRJNA821608 | ENA

Requirement of hepatic pyruvate carboxylase during fasting, high fat and ketogenic diet