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UnknownComparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.
Not available
S-EPMC6037860 | biostudies-literature
ProteomicsRequirement of hepatic pyruvate carboxylase during fasting, high fat and ketogenic diet
Pyruvate has two major fates upon entry into mitochondria, the oxidative decarboxylation to acetyl-CoA or the biotin-dependent carboxylation to oxaloacetate via pyruvate carboxylase (Pcx). Here we have generated mice with a liver specific knockout of pyruvate carboxylase (PcxL-/-) to understand the...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-31 | PXD032028 | Pride
Ketogenesis Acetyl-proteomics Pyruvate carboxylase Mitochondria 
ProteomicsIn-depth Profiling and Quantification of the Acetylproteome in Hepatocellular Carcinoma with a Trapped Ion Mobility Mass Spectrometer
In this study, we employed an integrated proteomics and acetyl-proteomics strategy to characterize of 8 tumors and 8 matched normal adjacent tissues (NATs) with 4D proteomics technology. Proteomics analysis identified a total of 6551 proteins, of which 5411 proteins were quantified across all sample...
ORGANISM(S): Homo sapiens (Human) 
2022-07-02 | PXD026729 | Pride
Pasef Proteomics Acetyl-proteomics Hepatocellular carcinoma Sirt2 Timstof pro Non-histone Cellular metabolism 
UnknownProteomics and acetyl-proteomics reveal the antibacterial mechanism of berberine sulfate against methicillin-resistant Staphylococcus aureus.
Not available
S-EPMC12847299 | biostudies-literature
OtherDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming (CRISPR)
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-09 | GSE240870 | GEO
TranscriptomicsDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming (RNA-seq_2)
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-09 | GSE240868 | GEO
OtherDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming (H3K27ac Cut&Tag)
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-09 | GSE240353 | GEO
GenomicsDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming [CUT&Tag]
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-09 | GSE296631 | GEO
GenomicsDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming (ATAC-seq)
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-09 | GSE240352 | GEO
TranscriptomicsDerepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
Metabolites are essential substrates for epigenetic modifications. Although nuclear acetyl-CoA constitutes a small fraction of the whole cell pool, it regulates cell fate by locally providing histone acetylation substrate. Here, we report a nucleus-specific acetyl-CoA regulatory mechanism that can b...
ORGANISM(S): Homo sapiens 
2025-05-08 | GSE240355 | GEO
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