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MetabolomicsTargeting Sirt2 reprograms T cell metabolism for effective immune response
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ORGANISM(S): Mus musculus 
ST001373 | MetabolomicsWorkbench
ProteomicsSIRT2 interactomics in HeLa cells
We aim to discovery new interactors of the deacetylase, SIRT2 from HeLa cells.
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD045456 | Pride
Sirt2 
Transcriptomicstranscriptome analysis of SIRT2 dependent genes modulated during infection by Listeria monocytogenes
tissue culture cells were treated with an inhibitor to the deacetylase SIRT2 (AGK2) and infected with Listeria monocytogenes
ORGANISM(S): Homo sapiens 
2013-06-01 | E-MEXP-3912 | biostudies-arrayexpress
ProteomicsProteomics-based identification of SIRT2 interaction partners
The NAD+ dependent deacetylase enzyme SIRT2 functions in diverse cellular processes including the cell cycle, metabolism and has recently been demonstrated to have important roles during tumorigenesis and bacterial infection. Though predominantly localised in the cytoplasm SIRT2 has been shown to co...
ORGANISM(S): Homo sapiens (Human) 
2020-02-20 | PXD011523 | Pride
Ap-ms Tumorigenesis Bacterial infection Sirt2 Nuclear translocation 
ProteomicsA Metabolite-bridged complex between SerRS and SIRT2 couples NAD+ metabolism to translation control
Cellular homeostasis requires tight coordination between metabolic and translational networks. Here we identify a direct molecular link between these processes through a cryo-EM structure of human cytosolic seryl-tRNA synthetase (SerRS) in complex with the NAD⁺-dependent deacetylase SIRT2. This inte...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD079339 | Pride
Serrs Nad+ metabolite Translational control Sirt2 Adp-ribose Oxidative stress 
ProteomicsSirt2 inhibition reprograms T cell metabolism for optimal anti-tumor immunity: Sirt2 Interacting Proteins
Growing evidence indicates that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However, the mechanisms underlying the m...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-15 | PXD012811 | Pride
T cell Sirtuin 2 Metabolism Interacting proteins Glycolysis 
ProteomicsSirt2 inhibition reprograms T cell metabolism for optimal anti-tumor immunity: Sirt2 Interacting Proteins 2
Growing evidence indicates that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However, the mechanisms underlying the m...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-03 | PXD020150 | Pride
T cell Sirtuin 2 Metabolism Interacting proteins Glycolysis 
ProteomicsAcetylation of p73 in 293T cell
293T cells ectopically expressing FLAG-tagged p73 were treated with AGK2 and p73 was immunoprecipitated. The precipitants were resuspended in deacetylation buffer (50 mM Tris-HCl pH 8.0, 140 mM NaCl, 2 mM MgCl 2 ) and incubated with recombinant SIRT2 protein (10 U). The reaction was terminated by bo...
ORGANISM(S): Homo Sapiens (human) 
2018-09-10 | PXD010411 | JPOST Repository
ProteomicsMetabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the “Warburg effect”, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD006036 | Pride
Acetylation Sirt2 Differentiation Human pluripotent stem cells 
ProteomicsSirt2 regulates liver metabolism in a sex-specific manner
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that Sirt2-/- males, but not females, have decreased body fat, moderate hypoglycemia upon fasting, a...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-19 | MSV000095391 | MassIVE
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