Sort   by:  
 Page size 
ProteomicsIdentifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA
Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubili...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD040663 | Pride
Mitochondria Pyrvinium pamoate Jurkat t cells Pisa 
GenomicsMIA-PaCa2 cells treated with Pyrvinium Pamoate, Rotenone, Oligomycin or Control
MIA-PaCa2 cells treated with Pyrvinium Pamoate, Rotenone, Oligomycin or Control
PRJNA735746 | ENA
GenomicsPyrvinium pamoate targets to multiple vulnerabilities of Merkel cell carcinoma
Pyrvinium pamoate targets to multiple vulnerabilities of Merkel cell carcinoma
PRJNA955382 | ENA
TranscriptomicsTranscription profiling of human cancer cells treated with unfolded protein response modulators under endoplasmic reticulum stress conditions
The unfolded protein response (UPR) is a cellular defense mechanism against glucose deprivation, a cell condition that occurs in solid tumors. A key feature of the UPR is the activation of the transcription program that allows the cell to cope with endoplasmic reticulum (ER) stress. We used micoarra...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13548 | biostudies-arrayexpress
TranscriptomicsMIA-PaCa2 cells treated with Pyrvinium Pamoate, Rotenone, Oligomycin or Control
Purpose: To compared Pyrvinium Pamoate induced transcription changes with known mitochondrial inhibitors. Methods: MIA-PaCa2 cells were treated with Pyrvinium Pamoate at 0.3µM, Oligomycin at 4µM or rotenone at 0.5 µM for 48 hours and then RNA was collected.
ORGANISM(S): Homo sapiens 
2022-06-03 | GSE176305 | GEO
TranscriptomicsPyrvinium pamoate targets to multiple vulnerabilities of Merkel cell carcinoma
Among several WNT signaling perturbagens, we identified pyrvinium pamoate, an FDA-approved anthelminthic drug that exhibits anti-tumor abilities in multiple cancers. Through the integration of transcriptomic, network, and molecular analyses, we discovered that pyrvinium is broadly effective against ...
ORGANISM(S): Homo sapiens 
2023-11-06 | GSE229701 | GEO
GenomicsEffect of pyrvinium pamoate on transcriptome and signaling pathways in FLT3-ITD acute leukemic cell line Molm13
Effect of pyrvinium pamoate on transcriptome and signaling pathways in FLT3-ITD acute leukemic cell line Molm13
PRJNA644354 | ENA
UnknownPyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads.
Not available
S-EPMC8880385 | biostudies-literature
GenomicsEffect of acute pyrvinium pamoate treatment on gene expression of CD4+ T cells during early activation.
Effect of acute pyrvinium pamoate treatment on gene expression of CD4+ T cells during early activation.
PRJNA954753 | ENA
TranscriptomicsEffect of pyrvinium pamoate on transcriptome and signaling pathways in FLT3-ITD acute leukemic cell line Molm13
To identify molecular effects of a classical anthelmintic pyrvinium pamoate(PP), we applied gene expression profiling in human acute leukemic cell line FLT3-ITD+ Molm13 using Whole Transcriptome Shotgun Sequencing (RNA-seq) after 6 h treatment with 50nM or 100nM pyrvinium. We got 94 and 219 differen...
ORGANISM(S): Homo sapiens 
2021-12-29 | GSE153854 | GEO
Sort   by:  
 Page size