Pisa - OmicsDI

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Ordinary differential equation model (2)

Lab affiliation

Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17177, Sweden (3)
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Department Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy (1)
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Department of Medicine, Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA (1)
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Chemical Proteomics, Division of Physiological Chemistry I, Dept. of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden. (1)
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA (1)
Fondazione Pisana per la Scienza ONLUS, 56107 San Giuliano Terme (PI), Italy (1)
Department of Chemistry, Boston University, USA (1)
Fondazione Pisana per la Scienza, ONLUS, San Giuliano Terme, Pisa, Italy (1)
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Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy. (1)
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Department of Genome Sciences, University of Washington, USA (1)
Chemical Proteomics core facility Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet, Sweden (1)

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Immuno-oncology (2)

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RNA-seq of coding RNA (1)

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One-Pot Time-Induced Proteome Integral Solubility Alteration (OPTI-PISA) assay for automated and sensitive drug target identification

Proteome Integral Solubility Alteration (PISA) assay is widely used for identifying drug targets, but it is labour-, sample and time-consuming. Aiming at enabling automation and greatly reducing the sample amount, we developed One-Pot Time-Induced (OPTI)-PISA. Here we demonstrate OPTI-PISA performan...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD050241 | Pride

Six-Year Prescription Pattern of Antimicrobial Use in Cats at the Veterinary Teaching Hospital of the University of Pisa.

Not available

S-EPMC10854698 | biostudies-literature

The Vascular Flora of Pisa (Tuscany, Central Italy).

Not available

S-EPMC11819712 | biostudies-literature

PISA Assay of B1 antibiotic on Neisseria gonorrhoeae

Study on antibiotic B1 and for target identification and mode of action characterization on Neisseria gonorrhoeae Strain, using Proteome Integral Solubility Alteration (PISA) Assay

ORGANISM(S): Neisseria gonorrhoeae

2026-01-19 | PXD063107 | Pride

Proteomics Lc-ms Mode of action Antibiotic Target id Bacteria Pisa assay

Identifying Ceramide Protein Interactions using PISA

Ceramides are potent influencers of cell fate and function; however, their direct molecular target(s) and mechanism of action are poorly understood. In this study, we treated primary proximal tubule epithelial cells with C2-ceramide (50uM) or its precursor C2-dihydroceramide (50uM) and used proteome...

ORGANISM(S): Mus musculus (Mouse)

2026-06-08 | PXD067617 | Pride

Ptec Mouse Pisa

Improved drug-target deconvolution with PISA-DIA using an extended, overlapping temperature gradient

For target-engagement applications, a comparative analysis was performed to assess the suitability, ease of implementation and cost-effectiveness between Cellular Thermal Shift Assay (CETSA) and Proteome Integral Solubility Alteration (PISA). Human multiple myeloma cells U266B1 cell lysate was treat...

ORGANISM(S): Homo sapiens (Human)

2024-05-20 | PXD044545 | Pride

Data independent acquisition (dia) Thermal proteome profiling Proteomics Mass spectrometry Target engagement Protein stability Proteome integral solubility alternation

Microplastic pollution in the sediments of interconnected lakebed, seabed, and seashore aquatic environments: polymer-specific total mass through the multianalytical "PISA" procedure.

Not available

S-EPMC10285023 | biostudies-literature

Proteome integral solubility alteration (PISA) analysis of compound treated Haemonchus contortus

This study applied the proteome integral solubility alteration (PISA) assay to infer molecular targets and protein–ligand interactions of candidate nematocidal compound in Haemonchus contortus. By monitoring compound-induced shifts in protein solubility across a temperature gradient, the analysis pr...

ORGANISM(S): Haemonchus contortus (Barber pole worm)

2026-07-19 | PXD075263 | Pride

Haemonchus contortus Proteomics Anthelmintic Pisa assay

3D tower of pisa

PRJNA1355058 | ENA

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

Multifaceted interrogation of the proteome deepens the system-wide understanding of biological systems; however, mapping the redox changes in the proteome has so far been significantly less informative than expression and solubility/stability analyses. Here, we devise the first high-throughput redox...

ORGANISM(S): Homo sapiens (Human)

2024-08-10 | PXD042967 | Pride

Multidimensional Proteomics Reactive oxygen species Mass spectrometry Interferon Stability

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