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Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo sapiens (Human) 
2017-01-17 | PXD003811 | Pride
Molecular phenotyping of antisense oligonucleotides (ASOs) in immortalized proximal tubule epithelial cells (PTEC-TERT1)
O-GlcNAcylation is a global post translational modification. The purpose of this study is to investigate the role of O-GlcNAcylation in mice kidney proximal tubules. We used drug-inducible proximal tubular cells specific O-GlcNAc transferase (Ogt) KO mice (PTEC-Ogt KO). In this proteomic analysis, w...
ORGANISM(S): Mus Musculus (mouse) 
For determination of the changes in PTEC gene expression caused by DNA DSBs, RNA-seq analysis was performed.
ORGANISM(S): Mus musculus 
2024-12-24 | GSE285052 | GEO
Cardiac LIM protein (CSRP3) is released from the heart after cardiac injury and transits the plasma to the renal filtrate. CSRP3 has a well described transcriptionally-active role in myocardiocyte development and response to stress. Although it appears in endocytic vesicles within tubular epithelial...
ORGANISM(S): Homo sapiens 
2025-08-20 | GSE276233 | GEO
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD), and few treatment options are available today to prevent the progressive loss of renal function. Tubular abnormalities may precede glomerular pathology early and indicate the functional progression of DKD, however...
ORGANISM(S): Mus musculus 
2025-07-18 | GSE253774 | GEO
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
Angiotensin II (AngII), the effector of the renin angiotensin system causes kidney disease progression by signalling through AT-1 receptor, but there are no measures of AngII activity in the kidney. Accordingly, we sought to define an AngII-regulated proteome in primary human proximal tubular epithe...
ORGANISM(S): Homo sapiens (Human) 
2013-07-18 | PXD000183 | Pride
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