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TranscriptomicsB cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62063 | biostudies-arrayexpress
UnknownEffect quantification and value prediction of factors in noninvasive detection for specific fetal copy number variants by semiconductor sequencing.
Not available
S-EPMC6625335 | biostudies-literature
ProteomicsOn-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions
The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA sp...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD079783 | Pride
Kinase inhibitor Ots964 Splicing Cdk11 Cell cycle 
TranscriptomicsAb initio identification of transcription start sites (TSSs) in the Rhesus macaque genome by histone modification and RNA-Seq
We addressed the lack of experimentally supported transcript annotations in the Rhesus macaque genome by ab initio identification of the transcription start sites (TSSs). We took advantage of histone H3 lysine 4 trimethylation (H3K4me3)'s ability to mark TSSs and the recently developed ChIP-Seq and ...
ORGANISM(S): Macaca mulatta 
2010-10-18 | E-GEOD-24538 | biostudies-arrayexpress
UnknownConstruction of a High-Density Paulownia Genetic Map and QTL Mapping of Important Phenotypic Traits Based on Genome Assembly and Whole-Genome Resequencing.
Not available
S-EPMC10647314 | biostudies-literature
ProteomicsSerum Peptidome Profiles Immune Response of COVID-19 Vaccine Administration
The study shows the promise of MALDI-TOF MS-based serum peptidome analysis for the assessment of immune responses activated by COVID-19 vaccination, and discovered a panel of serum peptides biomarkers for COVID-19 vaccination and for NAbs generation. The method developed in this study can help not o...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036159 |
ProteomicsEfficacy and Mechanism of Buyang Huanwu Decoction in Patients with Ischemic Heart Failure: A Randomized, Double-blind, Placebo-controlled Trial Combined with Proteomic Analysis
To assess the efficacy and safety of BYHWD combined with guideline-guided pharmacotherapy in patients with IHF and explore the biological mechanism by which BYHWD exerts its efficacy.
ORGANISM(S): Homo Sapiens 
2021-11-17 | PXD029771 |
ProteomicsQuantitative proteomic analysis of global protein acetylation in PRRSV infected pulmonary alveolar macrophages
Porcine reproductive and respiratory syndrome (PRRS), which caused by the porcine reproductive and respiratory syndrome virus (PRRSV), is a serious viral disease affecting global swine industry. At present, PRRSV vaccines fail to prevent this disease. Consequently, new antiviral strategies to compen...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-12-11 | PXD016927 | Pride
Porcine reproductive and respiratory syndrome  tandem mass tag label lc-ms  post-translational modification  acetylation. 
UnknownMolecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNA.
Not available
S-EPMC9292132 | biostudies-literature
MetabolomicsEffects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
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