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ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo sapiens (Human) 
2017-12-01 | PXD005336 | Pride
Target Mass spectrometry Chemical proteomics Kinase inhibitors Clinical kinase inhibitors Selectivity Lc-ms/ms 
UnknownIdentification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers.
Not available
S-EPMC5071635 | biostudies-literature
UnknownEvaluation on the phenotypic diversity of Calamansi (Citrus microcarpa) germplasm in Hainan island.
Not available
S-EPMC8748621 | biostudies-literature
UnknownCritical length screening enables 19% efficiency in thick-film organic solar cells.
Not available
S-EPMC12594902 | biostudies-literature
ProteomicsEfficacy and Mechanism of Buyang Huanwu Decoction in Patients with Ischemic Heart Failure: A Randomized, Double-blind, Placebo-controlled Trial Combined with Proteomic Analysis
To assess the efficacy and safety of BYHWD combined with guideline-guided pharmacotherapy in patients with IHF and explore the biological mechanism by which BYHWD exerts its efficacy.
ORGANISM(S): Homo Sapiens 
2021-11-17 | PXD029771 |
UnknownIncreased expression of LCN2 formed a positive feedback loop with activation of the ERK pathway in human kidney cells during kidney stone formation.
Not available
S-EPMC7718880 | biostudies-literature
UnknownModal gain characteristics of a two-section InGaAs/GaAs double quantum well passively mode-locked laser with asymmetric waveguide.
Not available
S-EPMC8943184 | biostudies-literature
MetabolomicsLegume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification

Biological nitrogen fixation by free-living bacteria and rhizobial symbiosis with legumes plays a key role in sustainable crop production. Here, we study how different crop combinations influence the interaction between peanut plants and their rhizosphere microbiota via metabolite deposition and ...

2024-03-19 | MTBLS6537 | MetaboLights
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
UnknownToward human intervention-free clinical diagnosis of intracranial aneurysm via deep neural network.
Not available
S-EPMC7892358 | biostudies-literature
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