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ProteomicsTime-Dependent Proteome Study: Human-in-mouse xenograft breast cancer tumor samples (0, 5, 30, 60 min)
The objective of the Time-Dependent Proteome Study was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from human-in-mouse breast cancer tumor samples.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-30 | MSV000084260 | MassIVE
ProteomicsTime-Dependent Proteome Study: Human ovarian cancer tumor samples (0, 5, 30, 60 min)

The objective of the Time-Dependent Proteome Study, was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from patient-derived ovarian cancer tumors.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-05 | MSV000083107 | MassIVE
MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
MetabolomicsThe integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury

Objective: The leaves of Malus hupehensis (MH) are a medicinal and edible traditional Chinese medicine (TCM) with good liver protection, although its underlying mechanism remains unclear. In this study, a network pharmacology-integrated multi-omics method was used to explore the hepatoprotective ...

2026-05-01 | MTBLS13219 | MetaboLights
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
ProteomicsTuina reverses capsule fibrosis in Frozen Shoulder as indicated via protemocis
Frozen shoulder (FS) is a common disorder often treated with Tuina, but the mechanisms involved remain unclear. We employed proteomics to investigate the mechanisms associated with the treatment of capsule fibrosis in FS rats. We used a method composed of three weeks of cast immobilization to establ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-09 | PXD047467 | Pride
Frozen shoulder  tuina  proteomics  capsule  fibrosis  rat 
ProteomicsAnalysis of activated CD4T cells and OTUD1-deficient CD4T cells reveals novel target proteins and related signaling pathway affected by OTUD1
The goals of the study are to compare differently expressed proteins in activated CD4T and OTUD1-deficient CD4T cells. Proteomics was performed with activated CD4T and OTUD1-deficient CD4T cells (n = 3 for each group) to identify the differently expressed proteins and related signaling pathway affe...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD036217 | Pride
Proteomics Activated cd4t Signaling pathway Otud1 
ProteomicsTuina reverses capsule fibrosis in Frozen Shoulder as indicated via phosphoproteomics
Frozen shoulder (FS) is a common disorder often treated with Tuina, but the mechanisms involved remain unclear. We employed proteomics to investigate the mechanisms associated with the treatment of capsule fibrosis in FS rats. We used a method composed of three weeks of cast immobilization to establ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-09 | PXD047468 | Pride
Frozen shoulder  tuina  phosphoproteomics  capsule  fibrosis  rat 
MetabolomicsGut symbiotic bacteria-derived nicotinic acid regulates Bactrocera dorsalis reproduction

Depletion of gut commensal bacteria significantly reduced nicotinic acid (NA) levels in the hemolymph and ovaries of Bactrocera dorsalis, leading to impaired ovarian development. This inhibition was reversed by exogenous NA supplementation. We identified Enterobacter hormaechei as a key NA-produc...

2025-07-30 | MTBLS12798 | MetaboLights
ProteomicsSleep fragmentation exacerbates cardiac microvascular endothelial cell cuproptosis via promoting neutrophil extracellular trap formation in myocardial ischemia-reperfusion injury
Objective: This study aimed to investigate the relationship between sleep disorders and cardiac microvascular injury in myocardial ischemia-reperfusion injury (MI/RI) mice. Design: Mice were placed in a sleep deprivation chamber. The sweep bar moved along the bottom of the cage every 2 min during th...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD066510 | Pride
Myocardial ischemia-reperfusion injury  sleep fragmentation  neutrophil extracellular traps  cardiac microvascular endothelial cells  cuproptosis 
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