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ProteomicsEZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. We demonstrate that EZH2 directly interacts with both MYC family oncoproteins, MYC and MYC...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029652 | Pride
Mycn Ap-ms Myc Ezh2 
ProteomicsTherapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free dNTPs. How these metabolic processes are integrated to fuel tumorigenesis remains to be ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD043444 | Pride
Myc Plk1 Nudt1 Cancer，protac 
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