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Urea undergoes natural hydrolysis to form cyanate, a reactive species capable of inducing protein carbamylation. To determine whether elevated urea levels promote carbamylation of platelet proteins, whether this modification is mediated by the urea transporter B (UT-B) expressed on platelets, and wh...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-28 | PXD066058 | Pride
The concentration of blood urea is markedly elevated in patients with advanced chronic kidney disease (CKD). Urea undergoes natural hydrolysis to form cyanate, a reactive species capable of inducing protein carbamylation. To determine whether elevated urea levels promote carbamylation of platelet pr...
ORGANISM(S): Homo sapiens (Human) 
2026-05-28 | PXD067646 | Pride
2-methoxyestradiol (2ME2) induces mammary gland differentiation through amphiregulin-EGFR mediated signaling: molecular distinctions from the mammary gland of pregnant mice.High levels of 2ME2 are observed in the late stages of pregnancy. We investigated the role of 2ME2 on normal mammary gland de...
ORGANISM(S): Mus musculus 
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