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ProteomicsQuantitative photo-crosslinking mass spectrometry reveals protein structure response to environmental changes
Conformational changes of protein structures depend on their chemical and physical environment. Studying conformational changes depending on environmental parameters is notoriously difficult as many methods of structural biology are affected by parameters like temperature or pH. To make such conform...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-07-01 | PXD012939 | Pride
Data-independent acquisition Structural dynamics Human serum albumin Dia-qclms Quantitation Xi Cytochrome c Spectronaut Label-free Mass spectrometry Photo-crosslinking Cross-linking Sda 
ProteomicsReliable identification of protein-protein interactions by crosslinking mass spectrometry_Protein coelution
Quantitative proteomics dataset on soluble, SEC-fractionated high-molecular weight proteome of E. coli for protein coelution analysis. This data was used to identify proteins for a subsequent crosslinking mass spectrometry search (DB creation) and to correlate protein elution behaviour to validate/...
ORGANISM(S): Escherichia Coli 
PXD019004 | JPOST Repository
ProteomicsReliable identification of protein-protein interactions by crosslinking mass spectrometry_AP-MS
Quantitative proteomics dataset on soluble, affinity-enriched proteins from SPA-pulldowns in E. coli K12, on rpoB-SPA / nusG-SPA / yacL-SPA. This data was used to identify proteins for enrichment analysis and subsequent crosslinking mass spectrometry search (DB creation). Cleared E. coli lysate was ...
ORGANISM(S): Escherichia Coli 
PXD024146 | JPOST Repository
UnknownQuantitative Photo-crosslinking Mass Spectrometry Revealing Protein Structure Response to Environmental Changes.
Not available
S-EPMC6639777 | biostudies-literature
UnknownChemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry.
Not available
S-EPMC12359043 | biostudies-literature
ProteomicsReliable identification of protein-protein interactions by crosslinking mass spectrometry_CLMS_BS3&DSSO_datasets
Crosslink mass spectrometry dataset on soluble, SEC-fractionated high-molecular weight proteome of E. coli, crosslinked with BS3 or DSSO. This data was used to identify protein-protein interactions and to obtain information on protein (complex) topologies. In the end, the data was used for finding ...
ORGANISM(S): Escherichia Coli 
PXD019120 | JPOST Repository
ProteomicsLarge-scale qualitative and quantitative research of dityrosine crosslinking omics in Escherichia coli
Excessive reactive oxygen species cause oxidative stress in cells. Two molecules of tyrosine can generate dityrosine, which is not only a product of natural posttranslational processes, but also a putative biomarker for protein oxidation. Few studies have investigated dityrosine crosslinking under e...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD039132 | Pride
Hydrogen peroxide Dityrosine crosslinking Label-free proteomics 
ProteomicsIsobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes
Dynamic conformational and structural changes in proteins and protein complexes play a central and ubiquitous role in the regulation of protein function, yet it is very challenging to study these changes, especially for large protein complexes, under physiological conditions. Here we introduce a nov...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-13 | PXD056825 | Pride
Isobaric crosslinkers Qclms Conformational changes Quantitative crosslinking mass spectrometry 
ProteomicsAnalysis of bilirubin-induced bovine serum albumin stability using protein denaturation and quantitative cross-linking mass spectrometry
We report the combination of protein-denaturation stability principles with quantitative cross-linking mass spectrometry using isobaric quantitative protein interaction reporter technologies. This method enables the evaluation of ligand-induced protein engagement through analysis of cross-link rela...
ORGANISM(S): Bos taurus (Bovine) 
2024-07-03 | PXD036649 | Pride
Quantitative cross-linking Protein stability Mass spectrometry 
UnknownAn integrated workflow for crosslinking mass spectrometry
Not available
S-SCDT-MSB-19-8994 | biostudies-other
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