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TranscriptomicsTranscription profiling of two human colon cancer cell lines derived from a primry tumor and a lypmh node metastatsis from a single patient reveals global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis.
Two colon cancer cell lines are under study. SW480 and SW620. The first one is derived from primary cancer, SW620 are from lymphnode metastatic sites. they both come from the sample patient. Polysomal RNA fractions from the two isogenic colon cancer cells lines was purified by sucrose gradient and h...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colorectal cancer cell lines derived from a primary tumor and a corresponding lymph node metastasis from the same individual
SW480 and SW620 are colon cancer cells lines derived from a primary tumor and a corresponding metastasis from the same individual. The numbers indicate the three independent replicate RNA samples processed. Three different software packages were used in parallel for signal calculation: Affymetrix mi...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1323 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translatome profiling of CPX 90m effects in neuroblastoma cells CHP134
Neuroblastoma (NB) is the most frequent extracranial solid tumour of childhood. Clinical courses are highly variable, ranging from spontaneous regression/maturation to rapid progression despite intensive multimodal therapy. The estimation of 5-year event free survival in high-risk patients of only a...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-60675 | biostudies-arrayexpress
TranscriptomicsTranslatome and transcriptome profiling of estradiol response in MCF7 cells
We subjected MCF7 cells to starvation with 0.5% charcoal treated serum for 48h and then we added 17-beta estradiol (E2) at final concentration of 10 nM, profiling before and after 60 minutes of treatment the transcriptome and the translatome, coming from the polysomal pool of mRNAs after sucrose gra...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22012 | biostudies-arrayexpress
TranscriptomicsTranslatome and transcriptome profiling of SH-SY5Y cells treated with sublytic doses of staphylococcal alpha-hemolysin
Genome-wide analysis of translation has the potential to provide major contributions in understanding the pathophysiology of infection processes, given the complex interplay between pathogens and host cells. Informations about the translational state of mRNAs or the activity of RNA binding proteins ...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-50652 | biostudies-arrayexpress
UnknownRobot-assisted retroperitoneal lymph node dissection in testicular cancer: state of the art and future perspectives.
Not available
S-EPMC12748088 | biostudies-literature
TranscriptomicsRIP-chip of HuR in MCF7 cells exposed to doxorubicin
The purpose of the study was to identify mRNA bound to HuR in the presence of doxorubicin in MCF7 cells. We collected cytoplasmic RNA from untreated and treated cells and detected differentially expressed genes (DEGs). We also coimmunoprecipitated HuR and IgG (as control) from doxorubicin treated ce...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-33055 | biostudies-arrayexpress
TranscriptomicsTranslatome and transcriptome profiling of EGF response in HeLa cells
Translatome analysis by sucrose gradient centrifugation of cell lysates followed by microarray profiling of the polysomal and subpolysomal RNA fractions represents a way of both studying translational control networks and better approximating the proteomic representation of cells. It is an establish...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20277 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translatome profiling of CPX 24h effects in neuroblastoma cells CHP134
Neuroblastoma (NB) is the most frequent extracranial solid tumour of childhood. Clinical courses are highly variable, ranging from spontaneous regression/maturation to rapid progression despite intensive multimodal therapy. The estimation of 5-year event free survival in high-risk patients of only a...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-53187 | biostudies-arrayexpress
TranscriptomicsIdentification of novel copy number alterations by high-resolution aCGH from FFPE cutaneous melanoma samples
We investigated a cohort of 34 archival cutaneous melanoma samples by Agilent 40 kb-resolution CGH array. We found a non-random distribution of precise CNAs predictive for clinical outcome. Although most of the alterations defined in this study have been already reported, we mapped novel melanoma-s...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-45354 | biostudies-arrayexpress
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