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TranscriptomicsRNA sequencing of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib
Mutations in isocitrate dehydrogenase 2 (IDH2) occur in many cancers including Acute Myeloid Leukemia (AML). Recently, we showed that single agent Enasidenib, a first-in-class, selective mutant IDH2 inhibitor, produces a 40% response in relapsed/refractory AML patients by promoting differentiation o...
ORGANISM(S): Homo sapiens 
2018-08-08 | E-MTAB-6660 | biostudies-arrayexpress
TranscriptomicsFunctional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors
Cord blood (CB) samples from normal donors were obtained with informed consent. Fresh CB samples were processed within 18-34h after collection. Mononuclear cells were isolated and CD34+ fraction was separated. CB CD34+ enriched fraction was lineage depleted by staining with purified anti-human CD2, ...
ORGANISM(S): Homo sapiens 
2017-10-03 | E-MTAB-5456 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human Acute Myeloid Leukemia samples
Not available
ORGANISM(S): Homo sapiens 
2011-01-21 | E-TABM-978 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of Esophageal Adenocarcinomas DAC
Data Access Committee EGAC00001000192
EGAC00001000192 | EGA
GenomicsGenomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic drivin...
EGAS00001000750 | EGA
GenomicsQCMG_20140410_OESO - samples
Description not provided
EGAD00001000845 | EGA
TranscriptomicsFunctional and genetic heterogeneity of distinctive leukaemic stem cell populations in CD34- human Acute Myeloid Leukaemia
We performed RNA-sequencing of normal haematopoietic stem cells and progenitor populations and of Leukemic Stem Cells in CD34- Acute Myeloid Leukaemia.
ORGANISM(S): Homo sapiens 
2016-06-22 | E-MTAB-2672 | biostudies-arrayexpress
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