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TranscriptomicsAnchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka
This study assessed the implications of a 14 day sub-chronic exposure of ethinylestradiol (EE2; 1.0 or 10.0 M-BM-5g/L EE2) on male medaka fertility, testicular histology and testicular gene expression. The findings demonstrate that a 14 day exposure to EE2 induced impaired male reproductive capacity...
ORGANISM(S): Oryzias latipes 
2013-03-06 | E-GEOD-44859 | biostudies-arrayexpress
GenomicsTargeting the SIN3A-PF1 Interaction inhibits Epithelial to Mesenchymal Transition and Maintenance of a Stem Cell Phenotype in Triple Negative Breast Cancer (MNase-seq)
Triple negative breast cancer (TNBC) is characterized by a poorly differentiated phenotype and limited treatment options. Aberrant epigenetics in this subtype represent a potential therapeutic opportunity, but a better understanding of the mechanisms contributing to the TNBC pathogenesis is required...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-73869 | biostudies-arrayexpress
TranscriptomicsReference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
The developmental potential of human pluripotent stem cells suggests that they can produce disease-relevant cell types for biomedical research. However, substantial variation has been reported among pluripotent cell lines, which could affect their utility and clinical safety. Such cell-line specific...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-GEOD-25970 | biostudies-arrayexpress
TranscriptomicsRole of miR-30 miRNAs during adipogenesis
Analysis of human adipose tissue-derived stem cells (hMADS cells) overexpressing either miR-30a or miR-30d, as well as knocked-down for the whole miR-30 family. Gene expression was analyzed after 4 days in adipogenic medium. Data give insight into the role of miR-30 during adipogenesis, and identifi...
ORGANISM(S): Homo sapiens 
2011-07-03 | E-GEOD-29207 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human mammary epithelial cell line MCF10A with RMRP/CCDC107/ARHGEF39-targeted CRISPR edits vs. scramble controls
The purpose of these experiments was to validate the role of a frequently mutated regulatory element bound by TOP2B using a functional genomics approach. Specifically, CRISPR/Cas9 was employed to selectively target the promoter of RMRP and non-coding regions of CCDC107 and ARHGEF39.
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14611 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of HT-29, MCF10A, and MDA-MB-436 cells
RNA-seq data from HT-29 cells treated with IFN-M-NM-3 for 24 hr, MCF10A cells, and MDA-MB-436 cells. mRNA profiles of HT-29, MCF10A, and MDA-MB-436 were generated by deep sequencing using Illumina HiSeq 2000. All RNA sequencing data was generated by the Genomics Services Lab at the HudsonAlpha Insti...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-45258 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of MCF7 with CARM1 knocked down
The goal of this study is to identify ERalpha-target genes affected by knocking down of the histone arginine methyltransferase CARM1 in MCF7 breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 knockingdown MCF7 cel...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26259 | biostudies-arrayexpress
TranscriptomicsHuman Calu-3 cell micro RNA transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in human Calu-3 cells infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), and AH - NS1-103F/106M. Human Calu-3 cells were seeded at 1 x 10^6 cells per well on 6 well plates 2 days before in...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-69027 | biostudies-arrayexpress
TranscriptomicsHuman Calu-3 cell transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in human Calu-3 cells infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Human Calu-3 cells were seeded at 1 x 10^6 cells per well...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-69026 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse aorta and vSMCs response to dioxin
We compared the global gene expression profiles of C57BL/6 mice aortas with the profiles of cultured vascular smooth muscle cells (vSMC) from the same mice, and determined whether gene responses to dioxin exposure in the vSMCs would be predictive of responses in the aorta.
ORGANISM(S): Mus musculus 
2003-10-29 | E-MEXP-23 | biostudies-arrayexpress
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