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ProteomicsPhosphoproteomic analysis of neoadjuvant breast cancer reveals a subset of patients with increased sensitivity to paclitaxel driven by CDK4 and Filamin A.
Precision oncology research is challenging outside contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is compl...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD034355 | Pride
Breast cancer Filamin a Phosphoproteomics Cdk4 Paclitaxel 
ProteomicsIn vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. We used high-throughput phosphoproteomics to build a functional TNBC taxonomy. A cluster of 159 phosphosites was upregulated in relapsed cases of a training set (n=34 patients). Eleven hyperactive kinases...
ORGANISM(S): Homo sapiens (Human) 
2018-07-23 | PXD008012 | Pride
Phophoproteomics Kinases Triple negative breast cancer 
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