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TranscriptomicsMicroarray analysis of human umbilical vein endothelial cells (HUVECs) chronically irradiated with low dose-rate of ionizing radiation for one, three and six weeks.
To obtain more insight in the molecular effects of chronic low dose irradiation on endothelial cells, HUVEC were irradiated with low-dose rate irradiation (137Cs gamma source; 0, 1.4 and 4.1 mGy/h) for several weeks. At different time points (1, 3 and 6 weeks) cells were harvested for RNA extraction...
ORGANISM(S): Homo sapiens 
2018-02-28 | E-MTAB-6521 | biostudies-arrayexpress
UnknownConvergence and divergence between the transcriptional responses to Zika virus infection and prenatal irradiation.
Not available
S-EPMC5386517 | biostudies-literature
TranscriptomicsRadiation exposure of mouse embryonic brain - 2 h, 24 h post-irradiation
The mammalian brain is especially sensitive to ionizing radiation during development, as shown by the increased occurrence of mental retardation and small head size in children who were in utero exposed to ionizing radiation after the atomic bombings of Hiroshima and Nagasaki. These effects of prena...
ORGANISM(S): Mus musculus 
2015-07-01 | E-MTAB-2720 | biostudies-arrayexpress
UnknownAn integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly.
Not available
S-EPMC10323360 | biostudies-literature
TranscriptomicsGene expression profiling of peripheral blood mononuclear cells (PBMCs) 8 hours after exposure to 1 Gy of carbon or iron ions
Under certain circumstances, humans can be exposed to ionizing radiation from heavy ions. Examples are cancer patients undergoing particle therapy (e.g. carbon ions) or astronauts in deep Space missions (iron ions which contribute for a large fraction to the possible health effects of cosmic radiati...
ORGANISM(S): Homo sapiens 
2018-02-21 | E-MTAB-5761 | biostudies-arrayexpress
TranscriptomicsRadiation exposure of human coronary artery endothelial cells - 1 day, 7 days, 14 days post-irradiation
In recent years there is a growing epidemiological indication of excess risk of cardiovascular disease at low doses of ionizing radiation without a clear-cut threshold. It is proposed that damage to the vascular endothelium is critical in radiation-related cardiovascular diseases. In order to identi...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-5054 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of primary mouse neural progenitor cells derived from the embryonic neocortex or medial ganglionic eminence at different time points after exposure to ionizing radiation
Embryonic DNA damage, e.g. resulting from exposure to moderate and high doses of ionizing radiation, has important consequences on the normal neurodevelopment, often resulting in microcephaly that can be associated with seizures. The effects of prenatal radiation exposure have previously been invest...
ORGANISM(S): Mus musculus 
2025-10-01 | E-MTAB-14528 | biostudies-arrayexpress
UnknownExposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.
Not available
S-EPMC6721538 | biostudies-literature
UnknownHippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease.
Not available
S-EPMC7655172 | biostudies-literature
UnknownThe combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor.
Not available
S-EPMC6956821 | biostudies-literature
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